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- W2885100309 abstract "OBJECTIVES:To look at the frequency of IL-28B polymorphisms in south Indian HIV infected individuals and its effect on IL-28 plasma level and immunological recovery following ART.METHODS:A total of 49 HIV infected individuals and 30 healthy controls were recruited. Whole blood samples were collected before and after 6-9 months of ART from patients. Absolute CD4+/CD8+ T cell counts, CD3+cell counts and CD4/CD8 ratio were estimated using flow cytometry (FACS Count). IL-28B polymorphism at rs12979860 and rs8099917 were detected by PCR-RFLP and IL-28B plasma level estimation was done by ELISA. Association between polymorphism, cell counts and IL-28 plasma level were analyzed.RESULTS:There was significant association of CC genotype at rs12979860 (p=0.03) and CC/TT haplotype (p=0.03) with higher CD4+T-cell count among treatment naive HIV infected individuals. There was a significant (p=0.03) association of CC/TT haplotype with increase in CD4/CD3% following ART. There was no correlation (p=>0.05) between IL-28B plasma level with IL-28B polymorphism, CD4+ T cell and CD4/CD8 ratio. There was no significant difference in the frequency of polymorphism and IL-28B plasma level between HIV infected individuals and healthy controls. The CT/GT haplotype had a significant higher IL-28B plasma level compared to wild type CC/TT before the initiation of ART and significantly higher decrease observed in CT/GT haplotype compared to CC/TT wild type were significant.CONCLUSION:In conclusion our preliminary data from this pilot study showed significantly higher CD4+ Tcellsamong HIV infected individuals with wild haplotype (CC/TT) prior to ART and significantly high CD4+ T cells and CD4/CD3% following ART. This study showed no association of IL-28B polymorphism with IL-28B plasma level and CD4+T cell count or CD4/CD8 ratio. Since IFNλ is a powerful immune modulator functional studies are warranted to understand the IFNλ mediated immuno-pathogeneis in HIV infection." @default.
- W2885100309 created "2018-08-22" @default.
- W2885100309 creator A5052718177 @default.
- W2885100309 date "2015-04-01" @default.
- W2885100309 modified "2023-09-27" @default.
- W2885100309 title "A Pilot study to look at the effect of IL-28B polymorphism on IL-28 expression and immunological recovery among HIV-1 infected individuals following Antiretroviral Therapy" @default.
- W2885100309 hasPublicationYear "2015" @default.
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