FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885102993> ?p ?o ?g. }

• W2885102993 abstract "Esophageal cancer is the eighth most common cancer in the world and it ranks sixth in mortality rate among cancer diseases. While patients with early stage esophageal cancer without metastasis have a better chance of being cured by surgery, most patients present with locally advanced or metastatic disease. Unfortunately, some common cancer biomarkers such as carcinoembryonic antigen (CEA) and CA19-9 have low sensitivity and specificity in esophageal cancer. A better understanding of the molecular mechanisms underlying esophageal cancer progression is needed to identify novel diagnostic markers and therapeutic targets for intervention. We previously identified serglycin (SRGN) as the top upregulated gene in a highly invasive esophageal squamous cell carcinoma (ESCC) cell subline. Serglycin is a proteoglycan with a core protein and glycosaminoglycan (GAG) chains. Its significance in tumorigenesis is not well understood. The GAG chains have the ability of binding specific growth factors and ligands, which may play an important role in facilitating cancer cell migration and invasion. Immunohistochemical analysis showed that serglycin expression was higher in ESCC compared with normal esophageal epithelium, and in lymph node metastases compared with primary ESCC. Ectopic overexpression of serglycin in ESCC cells enhanced their migration and invasion potential in vitro. Knockdown of serglycin reduced ESCC cell migration and invasion. In invasion chamber assays, conditioned medium (CM) from SRGN-overexpressing ESCC cells stimulated the migration and invasion ability of less invasive ESCC cells. Conditioned medium from ESCC cells expressing serglycin that lacks the GAG attachment site had no such effects. Chemokine antibody array analysis showed that midkine (MDK), a heparin-binding growth factor, was the top upregulated protein in the CM of SRGN-overexpressing cells. Analysis of TCGA and GTEx datasets showed that MDK expression was higher in many cancer types such as breast cancer, colon adenocarcinoma, glioblastoma and lung cancer, than in corresponding normal tissues. Western blot analysis showed that forced expression of serglycin, but not serglycin without the GAG binding domain, led to increase of MDK in the CM of multiple ESCC cell lines. Forced expression of serglycin also increased the expression level of phosphorylated extracellular signal-regulated kinase (p-ERK) in ESCC cells. Taken together, serglycin may play an important role in the progression ESCC by promoting migration and invasion of cancer cells. These effects may be mediated through activation of the ERK signaling pathway. Whether MDK is involved in this regulatory mechanism warrants further investigation." @default.
• W2885102993 created "2018-08-22" @default.
• W2885102993 creator A5008295370 @default.
• W2885102993 creator A5027913321 @default.
• W2885102993 creator A5029695887 @default.
• W2885102993 creator A5081753595 @default.
• W2885102993 creator A5086159719 @default.
• W2885102993 creator A5090438506 @default.
• W2885102993 date "2018-07-01" @default.
• W2885102993 modified "2023-10-14" @default.
• W2885102993 title "Abstract 3168: Serglycin promotes migration and invasion of esophageal cancer cells" @default.
• W2885102993 doi "https://doi.org/10.1158/1538-7445.am2018-3168" @default.
• W2885102993 hasPublicationYear "2018" @default.
• W2885102993 type Work @default.
• W2885102993 sameAs 2885102993 @default.
• W2885102993 citedByCount "0" @default.
• W2885102993 crossrefType "proceedings-article" @default.
• W2885102993 hasAuthorship W2885102993A5008295370 @default.
• W2885102993 hasAuthorship W2885102993A5027913321 @default.
• W2885102993 hasAuthorship W2885102993A5029695887 @default.
• W2885102993 hasAuthorship W2885102993A5081753595 @default.
• W2885102993 hasAuthorship W2885102993A5086159719 @default.
• W2885102993 hasAuthorship W2885102993A5090438506 @default.
• W2885102993 hasBestOaLocation W28851029931 @default.
• W2885102993 hasConcept C11957725 @default.
• W2885102993 hasConcept C121608353 @default.
• W2885102993 hasConcept C126322002 @default.
• W2885102993 hasConcept C137738243 @default.
• W2885102993 hasConcept C142724271 @default.
• W2885102993 hasConcept C1491633281 @default.
• W2885102993 hasConcept C173396325 @default.
• W2885102993 hasConcept C2777387746 @default.
• W2885102993 hasConcept C2779013556 @default.
• W2885102993 hasConcept C2779742542 @default.
• W2885102993 hasConcept C502942594 @default.
• W2885102993 hasConcept C54355233 @default.
• W2885102993 hasConcept C555283112 @default.
• W2885102993 hasConcept C71924100 @default.
• W2885102993 hasConcept C81885089 @default.
• W2885102993 hasConcept C86803240 @default.
• W2885102993 hasConcept C96232424 @default.
• W2885102993 hasConcept C97037327 @default.
• W2885102993 hasConceptScore W2885102993C11957725 @default.
• W2885102993 hasConceptScore W2885102993C121608353 @default.
• W2885102993 hasConceptScore W2885102993C126322002 @default.
• W2885102993 hasConceptScore W2885102993C137738243 @default.
• W2885102993 hasConceptScore W2885102993C142724271 @default.
• W2885102993 hasConceptScore W2885102993C1491633281 @default.
• W2885102993 hasConceptScore W2885102993C173396325 @default.
• W2885102993 hasConceptScore W2885102993C2777387746 @default.
• W2885102993 hasConceptScore W2885102993C2779013556 @default.
• W2885102993 hasConceptScore W2885102993C2779742542 @default.
• W2885102993 hasConceptScore W2885102993C502942594 @default.
• W2885102993 hasConceptScore W2885102993C54355233 @default.
• W2885102993 hasConceptScore W2885102993C555283112 @default.
• W2885102993 hasConceptScore W2885102993C71924100 @default.
• W2885102993 hasConceptScore W2885102993C81885089 @default.
• W2885102993 hasConceptScore W2885102993C86803240 @default.
• W2885102993 hasConceptScore W2885102993C96232424 @default.
• W2885102993 hasConceptScore W2885102993C97037327 @default.
• W2885102993 hasLocation W28851029931 @default.
• W2885102993 hasOpenAccess W2885102993 @default.
• W2885102993 hasPrimaryLocation W28851029931 @default.
• W2885102993 hasRelatedWork W1502716441 @default.
• W2885102993 hasRelatedWork W2087990232 @default.
• W2885102993 hasRelatedWork W2107873095 @default.
• W2885102993 hasRelatedWork W2128946898 @default.
• W2885102993 hasRelatedWork W2487824964 @default.
• W2885102993 hasRelatedWork W2600717990 @default.
• W2885102993 hasRelatedWork W2741267727 @default.
• W2885102993 hasRelatedWork W2800031669 @default.
• W2885102993 hasRelatedWork W2937327588 @default.
• W2885102993 hasRelatedWork W3196377367 @default.
• W2885102993 isParatext "false" @default.
• W2885102993 isRetracted "false" @default.
• W2885102993 magId "2885102993" @default.
• W2885102993 workType "article" @default.