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- W2885103492 abstract "Objective— A decreased plasma level of adiponectin is associated with obesity and metabolic syndrome and correlated with endothelial dysfunction. This study aimed to investigate the regulated expression of the newly identified adiponectin receptors (AdipoR1 and 2) and their roles in the endothelial expression of intercellular adhesion molecule-1 (ICAM-1) in response to tumor necrosis factor (TNF)-α. Methods and Results— Immunohistochemical study and quantitative RT-PCR demonstrated that globular adiponectin suppressed the TNF-α–induced ICAM-1 expression in a dose-dependent manner in mouse aorta and human umbilical vein endothelial cells (HUVECs). Adenovirus-mediated overexpression of AdipoR1 and 2 in ECs significantly enhanced the suppressive effect of a subeffective dose of adiponectin on TNF-α–induced ICAM-1 expression and NF-κB activation. Promoter reporter assays and small interfering RNA revealed that peroxisome proliferator-activated receptor-α may function as an important pathway downstream of adip..." @default.
- W2885103492 created "2018-08-22" @default.
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- W2885103492 date "2009-01-01" @default.
- W2885103492 modified "2023-09-24" @default.
- W2885103492 title "Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells" @default.
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