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- W2885105504 abstract "Abstract HSCR (Hirschsprung's disease) is a serious congenital defect, and the aetiology of it remains unclear. Many studies have highlighted the significant roles of intronic mi RNA s and their host genes in various disease, few was mentioned in HSCR although. In this study, miR‐483‐3p along with its host gene IGF 2 (Insulin‐like growth factor 2) was found down‐regulated in 60 HSCR aganglionic colon tissues compared with 60 normal controls. FHL 1 (Four and a half LIM domains 1) was determined as a target gene of miR‐483‐3p via dual‐luciferase reporter assay, and its expression was at a higher level in HSCR tissues. Here, we study cell migration and proliferation in human 293T and SH ‐ SY 5Y cell lines by performing Transwell and CCK 8 assays. In conclusion, the knockdown of miR‐483‐3p and IGF 2 both suppressed cell migration and proliferation, while the loss of FHL 1 leads to opposite outcome. Furthermore, miR‐483‐3p mimics could rescue the negative effects on cell proliferation and migration caused by silencing IGF 2, while the FHL 1 si RNA may inverse the function of miR‐483‐3p inhibitor. This study revealed that miR‐483‐3p derived from IGF 2 was associated with Hirschsprung's disease by targeting FHL 1 and may provide a new pathway to understand the aetiology of HSCR ." @default.
- W2885105504 created "2018-08-22" @default.
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- W2885105504 date "2018-08-02" @default.
- W2885105504 modified "2023-10-17" @default.
- W2885105504 title "<scp>IGF</scp>2‐derived miR‐483‐3p associated with Hirschsprung's disease by targeting<scp>FHL</scp>1" @default.
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- W2885105504 doi "https://doi.org/10.1111/jcmm.13756" @default.
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