FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885117326> ?p ?o ?g. }

• W2885117326 endingPage "13" @default.
• W2885117326 startingPage "13" @default.
• W2885117326 abstract "Abstract Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2 (COX-2), which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzyme in PGE2 catabolism, converting it into its inactive metabolite 15-keto-PGE2 and is often down-regulated in cancer. Interesting enough, CRC patients expressing high levels of Cysteinyl leukotriene receptor 2 (CysLTR2) have a good prognosis and therefore, we investigated a potential link between CysLTR2-signaling and the tumor suppressor 15-PGDH in colon cancer cells. TNF-α is considered as the main regulators of COX-2 and mPGES-1 that contribute to the increased synthesis of PGE2, which is inhibited by overexpressed 15-PGDH. Level of the pro-tumorigenic PGE2 are increased in CRC, previously attributed to increased production via TNF-α mediated COX-2 up-regulation but more recently attributed to decreased catabolism due to down-regulation of 15-PGDH. Elevation of 15-PGDH expression by leukotriene C4 (LTC4), a CysLTR2 ligand, exhibited anti-tumor activity in colon cancer cells with significant phosphorylation of β-catenin and down-regulation of anti-apoptotic marker Bcl-2 with concurrent activation of CASPASE-3 expression. We also observed a dramatic down-regulation of TNF-α on mRNA level and NF-κβ on both mRNA as well as protein level with LTC4 induced 15-PGDH in a TNF-α dependent manner. Moreover, TNF-α regulated anti-angiogenic action of 15-PGDH in HT-29 and Caco-2 colon cancer cells by depleting the mRNA level of MMP-2 and MMP-9 and protein level of VEGFR-1. Furthermore, our preliminary observation also suggested disrupted tube formation in HUVEC with LTC4 induced 15-PGDH which is mediated by TNF-α. Hence, restoration of 15-PGDH expression through CysLTR2-signaling promotes the anti-angiogenic action against colon cancer cells, indicating an anti-tumor as well as the anti-metastatic efficacy of CysLTR2-signaling. Citation Format: Shakti R. Satapathy, Anita Sjölander. Anti-angiogenic action of leukotriene-C4induced 15-hydroxyprostaglandin dehydrogenase in colon cancer cells is a TNF-α dependent phenomenon [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 13." @default.
• W2885117326 created "2018-08-22" @default.
• W2885117326 creator A5020801794 @default.
• W2885117326 creator A5068014857 @default.
• W2885117326 date "2018-07-01" @default.
• W2885117326 modified "2023-10-16" @default.
• W2885117326 title "Abstract 13: Anti-angiogenic action of leukotriene-C4induced 15-hydroxyprostaglandin dehydrogenase in colon cancer cells is a TNF-α dependent phenomenon" @default.
• W2885117326 doi "https://doi.org/10.1158/1538-7445.am2018-13" @default.
• W2885117326 hasPublicationYear "2018" @default.
• W2885117326 type Work @default.
• W2885117326 sameAs 2885117326 @default.
• W2885117326 citedByCount "0" @default.
• W2885117326 crossrefType "journal-article" @default.
• W2885117326 hasAuthorship W2885117326A5020801794 @default.
• W2885117326 hasAuthorship W2885117326A5068014857 @default.
• W2885117326 hasConcept C121608353 @default.
• W2885117326 hasConcept C126322002 @default.
• W2885117326 hasConcept C134018914 @default.
• W2885117326 hasConcept C17991360 @default.
• W2885117326 hasConcept C185592680 @default.
• W2885117326 hasConcept C2777956040 @default.
• W2885117326 hasConcept C2780394083 @default.
• W2885117326 hasConcept C502942594 @default.
• W2885117326 hasConcept C526805850 @default.
• W2885117326 hasConcept C62231903 @default.
• W2885117326 hasConcept C71924100 @default.
• W2885117326 hasConcept C86803240 @default.
• W2885117326 hasConcept C96232424 @default.
• W2885117326 hasConcept C96942376 @default.
• W2885117326 hasConceptScore W2885117326C121608353 @default.
• W2885117326 hasConceptScore W2885117326C126322002 @default.
• W2885117326 hasConceptScore W2885117326C134018914 @default.
• W2885117326 hasConceptScore W2885117326C17991360 @default.
• W2885117326 hasConceptScore W2885117326C185592680 @default.
• W2885117326 hasConceptScore W2885117326C2777956040 @default.
• W2885117326 hasConceptScore W2885117326C2780394083 @default.
• W2885117326 hasConceptScore W2885117326C502942594 @default.
• W2885117326 hasConceptScore W2885117326C526805850 @default.
• W2885117326 hasConceptScore W2885117326C62231903 @default.
• W2885117326 hasConceptScore W2885117326C71924100 @default.
• W2885117326 hasConceptScore W2885117326C86803240 @default.
• W2885117326 hasConceptScore W2885117326C96232424 @default.
• W2885117326 hasConceptScore W2885117326C96942376 @default.
• W2885117326 hasIssue "13_Supplement" @default.
• W2885117326 hasLocation W28851173261 @default.
• W2885117326 hasOpenAccess W2885117326 @default.
• W2885117326 hasPrimaryLocation W28851173261 @default.
• W2885117326 hasRelatedWork W1968380023 @default.
• W2885117326 hasRelatedWork W1973441027 @default.
• W2885117326 hasRelatedWork W1990717759 @default.
• W2885117326 hasRelatedWork W2041324455 @default.
• W2885117326 hasRelatedWork W2088896559 @default.
• W2885117326 hasRelatedWork W2117869167 @default.
• W2885117326 hasRelatedWork W2151614054 @default.
• W2885117326 hasRelatedWork W2155784393 @default.
• W2885117326 hasRelatedWork W2748952813 @default.
• W2885117326 hasRelatedWork W4283771460 @default.
• W2885117326 hasVolume "78" @default.
• W2885117326 isParatext "false" @default.
• W2885117326 isRetracted "false" @default.
• W2885117326 magId "2885117326" @default.
• W2885117326 workType "article" @default.