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- W2885128859 abstract "This article describes the preparation and fundamental properties of a new possible material as a magnetic resonance imaging contrast agent based on the incorporation of preformed iron oxide (Fe3O4) nanocrystals into hollow silicon nanotubes (Si NTs). Specifically, superparamagnetic Fe3O4 nanoparticles of two different average sizes (5 nm and 8 nm) were loaded into Si NTs of two different shell thicknesses (40 nm and 70 nm). To achieve proper aqueous solubility, the NTs were functionalized with an outer polyethylene glycol-diacid (600) moiety via an aminopropyl linkage. Relaxometry parameters r1 and r2 were measured, with the corresponding r2/r1 ratios in phosphate buffered saline confirming the expected negative contrast agent behaviour for these materials. For a given nanocrystal size, the observed r2 values are found to be inversely proportional to NT wall thickness, thereby demonstrating the role of nanostructured silicon template on associated relaxometry properties." @default.
- W2885128859 created "2018-08-22" @default.
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- W2885128859 date "2018-08-01" @default.
- W2885128859 modified "2023-10-12" @default.
- W2885128859 title "New MRI contrast agents based on silicon nanotubes loaded with superparamagnetic iron oxide nanoparticles" @default.
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- W2885128859 doi "https://doi.org/10.1098/rsos.180697" @default.
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