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- W2885135384 abstract "Background: Anion-exchange chromatography has identified L5 as the most electronegative entity of charge-defined LDL subfractions, L1-L5. In patients with ST-elevation myocardial infarction, L5 is markedly elevated and can enhance platelet aggregation. To further evaluate its clinical relevance, we examined plasma L5 distributions in patients classified as the 4 statin benefit groups (atherosclerotic cardiovascular disease, LDL cholesterol >190 mg/dL, diabetes mellitus, 10-year cardiovascular risk score >7.5%) by the 2013 ACC/AHA guideline. Methods and results: By examining the medical history and clinical profiles, we divided a cohort of 62 asymptomatic patients (59.4±10.5 yr) with 2 or more components of the metabolic syndrome criteria into the statin benefit (n=44) and non-statin benefit (n=18) groups. Although the plasma LDL cholesterol levels did not differ between groups (147±35 vs. 153±49 mg/dL), the statin benefit group had significantly higher L5/LDL% (5.2±7.3% vs. 2.6±1.9%, P=0.031) and L5 conce..." @default.
- W2885135384 created "2018-08-22" @default.
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- W2885135384 date "2014-11-25" @default.
- W2885135384 modified "2023-09-26" @default.
- W2885135384 title "Abstract 18817: The Four Statin Benefit Groups Defined by the 2013 ACC/AHA Guideline are Characterized by Increased Plasma Level of Electronegative LDL" @default.
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