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- W2885136235 abstract "Background and Purpose Tau-like immunoreactivity is known to develop in neurons under some experimental conditions simulating ischemia. The purpose of this study is to investigate the expression of tau-like immunoreactivity in the human brain after ischemic insult. Methods A series of autopsied human brains with or without ischemic lesion were investigated with immunohistochemistry (Alz-50, anti-tau, and anti-ubiquitin) and with silver-staining methods (Gallyas and Bodian methods). Results Punctate immunoreactivity to Alz-50 was visualized in the cytoplasm not only of the neurons in and around the ischemic lesion but also of the neurons free from classic ischemic changes around the necrosis. Some of the neurons around the ischemic lesion were stained by the Gallyas method. Immunostaining with anti-tau and anti-ubiquitin antibodies and the conventional Bodian method failed to visualize these neurons. Conclusions The widespread appearance of Alz-50 immunoreactive neurons during the ischemic process signifie..." @default.
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- W2885136235 date "1995-11-01" @default.
- W2885136235 modified "2023-09-23" @default.
- W2885136235 title "Widespread Appearance of Alz-50 Immunoreactive Neurons in the Human Brain With Cerebral Infarction" @default.
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