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- W2885145206 abstract "Adalimumab is one of the top-selling drugs worldwide. Its imminent patent expiration has seen the emergence of numerous biosimilar agents. In this article, we recap the evidence from bio-originator trials in rheumatoid arthritis (RA) to provide context for a critical review of biosimilar trial data.Currently, three adalimumab biosimilars are approved in Europe and/or the USA: Amgen's ABP 501 (AMJEVITA/Solymbic), Boehringer Ingelheim's BI 695501 (Cyltezo) and Samsung Bioepis's SB5 (Imraldi). All three agents met their pre-specified equivalence criteria. Subtle differences in adverse events and clinical responses between the reference and biosimilar products were noted. The introduction of adalimumab biosimilars will offer exciting opportunities in improving treatment access and increasing treatment options for RA and other licensed indications. Real-world data will further provide assurances on efficacy as well as safety." @default.
- W2885145206 created "2018-08-22" @default.
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- W2885145206 date "2018-08-09" @default.
- W2885145206 modified "2023-10-02" @default.
- W2885145206 title "Review of Biosimilar Trials and Data on Adalimumab in Rheumatoid Arthritis" @default.
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- W2885145206 doi "https://doi.org/10.1007/s11926-018-0769-6" @default.
- W2885145206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6097048" @default.
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