Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885145257> ?p ?o ?g. }
- W2885145257 endingPage "8089" @default.
- W2885145257 startingPage "8079" @default.
- W2885145257 abstract "Programmed –1 ribosomal frameshifting (−1PRF) is a recoding mechanism to make alternative proteins from a single mRNA transcript. −1PRF is stimulated by cis-acting signals in mRNA, a seven-nucleotide slippery sequence and a downstream secondary structure element, which is often a pseudoknot. In this study we engineered the frameshifting pseudoknot from the mouse mammary tumor virus to respond to a rationally designed small molecule naphthyridine carbamate tetramer (NCTn). We demonstrate that NCTn can stabilize the pseudoknot structure in mRNA and activate –1PRF both in vitro and in human cells. The results illustrate how NCTn-inducible –1PRF may serve as an important component of the synthetic biology toolbox for the precise control of gene expression using small synthetic molecules." @default.
- W2885145257 created "2018-08-22" @default.
- W2885145257 creator A5000082958 @default.
- W2885145257 creator A5004710853 @default.
- W2885145257 creator A5025064126 @default.
- W2885145257 creator A5078916199 @default.
- W2885145257 creator A5084871178 @default.
- W2885145257 date "2018-08-02" @default.
- W2885145257 modified "2023-10-06" @default.
- W2885145257 title "Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting" @default.
- W2885145257 cites W1563617971 @default.
- W2885145257 cites W1695243715 @default.
- W2885145257 cites W1839549959 @default.
- W2885145257 cites W1963716909 @default.
- W2885145257 cites W1972139720 @default.
- W2885145257 cites W1972906924 @default.
- W2885145257 cites W1975310984 @default.
- W2885145257 cites W1982169838 @default.
- W2885145257 cites W1984178383 @default.
- W2885145257 cites W1986023247 @default.
- W2885145257 cites W1987568156 @default.
- W2885145257 cites W1989297603 @default.
- W2885145257 cites W1989687714 @default.
- W2885145257 cites W1991738184 @default.
- W2885145257 cites W1992707483 @default.
- W2885145257 cites W1992918372 @default.
- W2885145257 cites W1997756012 @default.
- W2885145257 cites W2002673607 @default.
- W2885145257 cites W2003543791 @default.
- W2885145257 cites W2004121424 @default.
- W2885145257 cites W2007227203 @default.
- W2885145257 cites W2007909703 @default.
- W2885145257 cites W2009528855 @default.
- W2885145257 cites W2009543804 @default.
- W2885145257 cites W2012192331 @default.
- W2885145257 cites W2014839221 @default.
- W2885145257 cites W2015517893 @default.
- W2885145257 cites W2019875938 @default.
- W2885145257 cites W2022092530 @default.
- W2885145257 cites W2022208537 @default.
- W2885145257 cites W2029038593 @default.
- W2885145257 cites W2030621944 @default.
- W2885145257 cites W2031512086 @default.
- W2885145257 cites W2033946310 @default.
- W2885145257 cites W2036345369 @default.
- W2885145257 cites W2039553437 @default.
- W2885145257 cites W2041305309 @default.
- W2885145257 cites W2047004417 @default.
- W2885145257 cites W2047946060 @default.
- W2885145257 cites W2052812651 @default.
- W2885145257 cites W2053272506 @default.
- W2885145257 cites W2053811769 @default.
- W2885145257 cites W2053861881 @default.
- W2885145257 cites W2055060972 @default.
- W2885145257 cites W2055741356 @default.
- W2885145257 cites W2062540870 @default.
- W2885145257 cites W2067191137 @default.
- W2885145257 cites W2067258168 @default.
- W2885145257 cites W2070954834 @default.
- W2885145257 cites W2073636715 @default.
- W2885145257 cites W2076351580 @default.
- W2885145257 cites W2077994915 @default.
- W2885145257 cites W2078149628 @default.
- W2885145257 cites W2079031824 @default.
- W2885145257 cites W2081640821 @default.
- W2885145257 cites W2083147729 @default.
- W2885145257 cites W2085086400 @default.
- W2885145257 cites W2085802860 @default.
- W2885145257 cites W2087782006 @default.
- W2885145257 cites W2092435968 @default.
- W2885145257 cites W2092974248 @default.
- W2885145257 cites W2094552228 @default.
- W2885145257 cites W2101084790 @default.
- W2885145257 cites W2103078111 @default.
- W2885145257 cites W2116965666 @default.
- W2885145257 cites W2122996035 @default.
- W2885145257 cites W2123902202 @default.
- W2885145257 cites W2134410571 @default.
- W2885145257 cites W2134499928 @default.
- W2885145257 cites W2135229490 @default.
- W2885145257 cites W2136190231 @default.
- W2885145257 cites W2137144851 @default.
- W2885145257 cites W2137656412 @default.
- W2885145257 cites W2139802093 @default.
- W2885145257 cites W2139912474 @default.
- W2885145257 cites W2150147498 @default.
- W2885145257 cites W2158721036 @default.
- W2885145257 cites W2159678490 @default.
- W2885145257 cites W2167493273 @default.
- W2885145257 cites W2302027613 @default.
- W2885145257 cites W2312510963 @default.
- W2885145257 cites W2332158618 @default.
- W2885145257 cites W2399677155 @default.
- W2885145257 cites W2493667413 @default.
- W2885145257 cites W2949983130 @default.
- W2885145257 doi "https://doi.org/10.1093/nar/gky689" @default.
- W2885145257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6144811" @default.
- W2885145257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30085309" @default.