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• W2885149826 abstract "Substituted[4,5]thieno[2,3- d ]thiazolo[3,2- a ]pyrimidin-5-one ( 3a–b ) and pyrimidin-5(6 H )-imine ( 3c–e ) were synthesized via reaction of the starting compounds, ethyl 2-amino-substituted[ b ]thiophene-3-carboxylate ( 2a–c ) and 2-amino-substituted [ b ]thiophene-3-carbonitrile ( 2d–f ), respectively, with 2-bromothiazole. Synthesis of (bromo-substituted[ b ]thiophen-2-yl)alkanamide derivatives ( 4a–e ) and thieno[2,3- d ][1,3]oxazin-4-imine derivative ( 5 ) was accomplished via reaction of the starting compounds with bromoalkyl chloride through nucleophilic substitution; however, for the synthesis of compound 5 , nucleophilic substitution was followed by nucleophilic addition to a nitrile group to form the oxazinimine ring. 1-(3-cyano-substituted[ b ]thiophen-2-yl)-3-(4-(trifluoromethyl)phenyl)thiourea derivatives ( 6a–c ) were obtained via reaction of the starting compounds ( 2d–f ) and 4-(trifluoromethyl phenyl)isothiocyanate. The lead compounds ( 2d–f ) rapidly reacted with 4-(trifluoromethyl)benzaldehyde or 4-(2-pyridyl)benzaldehyde in acidic medium to yield compounds ( 7a–f) in large quantities. X-ray crystallography of compounds 4c and 7e confirmed their structures. Antimicrobial studies revealed that compound 6a was equally potent to ampicillin against Bacillus strains. Moreover, compounds 3e , 4d , and 6a possessed greater anti-inflammatory potency than that of the standard drug." @default.
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• W2885149826 date "2018-08-01" @default.
• W2885149826 modified "2023-10-14" @default.
• W2885149826 title "Synthesis, Characterization, and Antibacterial and Anti-Inflammatory Activities of New Pyrimidine and Thiophene Derivatives" @default.
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• W2885149826 doi "https://doi.org/10.1155/2018/8536063" @default.
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