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- W2885153522 abstract "Mitochondria are a keystone of neuronal function, serving a dual role as sustainer of life and harbinger of death. While mitochondria are indispensable for energy production, a dysregulated mitochondrial network can spell doom for both neurons and the functions they provide. Traumatic brain injury (TBI) is a complex and biphasic injury, often affecting children and young adults. The primary pathological mechanism of TBI is mechanical, too rapid to be mitigated by anything but prevention. However, the secondary injury of TBI evolves over hours and days after the initial insult providing a window of opportunity for intervention. As a nexus point of both survival and death during this second phase, targeting mitochondrial pathology in TBI has long been an attractive strategy. Often these attempts are mired by efficacy-limiting unintended off-target effects. Specific delivery to and enrichment of therapeutics at their submitochondrial site of action can reduce deleterious effects and increase potency. Mitochondrial drug localization is accomplished using (1) the mitochondrial membrane potential, (2) affinity of a carrier to mitochondria-specific components (e.g. lipids), (3) piggybacking on the cells own mitochondria trafficking systems, or (4) nanoparticle-based approaches. In this review, we briefly consider the mitochondrial delivery strategies and drug targets that illustrate the promise of these mitochondria-specific approaches in the design of TBI pharmacotherapy. This article is part of the Special Issue entitled “Novel Treatments for Traumatic Brain Injury”." @default.
- W2885153522 created "2018-08-22" @default.
- W2885153522 creator A5025786667 @default.
- W2885153522 creator A5027298576 @default.
- W2885153522 creator A5029785181 @default.
- W2885153522 creator A5030917251 @default.
- W2885153522 creator A5058521832 @default.
- W2885153522 creator A5072142191 @default.
- W2885153522 creator A5072770037 @default.
- W2885153522 date "2019-02-01" @default.
- W2885153522 modified "2023-10-16" @default.
- W2885153522 title "Aiming for the target: Mitochondrial drug delivery in traumatic brain injury" @default.
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