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• W2885158309 abstract "As the second most abundant transition metal after iron in biological systems, Zn2+ takes part in various fundamental life processes such as cellular metabolism and apoptosis, neurotransmission. Thus, the development of analytical methods for fast detection of Zn2+ in biology and medicine has been attracting much attention but still remains a huge challenge. In this report, we develop a novel Zn2+-specific light-up fluorescent probe based on intramolecular charge transfer combined with chelation enhanced fluorescence induced by structural transformation. Addition of Zn2+ in vitro can induce a remarkable color change from colorless to green and a strong fluorescence enhancement with a red shift of 43 nm. Moreover, the probe shows an extremely low detection limit of 13 nM and ultra-fast response time of less than 1 s. The Zn2+ sensing mechanism was fully supported by TDDFT calculations as well as HRMS and 1H NMR titrations. The recognition of Zn2+ in living Hela cells as well as the MTT assay demonstrate that the probe can rapidly light-up detect Zn2+ in vivo with low cytotoxicity and good cell-permeability. Furthermore, the probe can also be successfully applied to bioimaging Zn2+ in living zebrafish." @default.
• W2885158309 created "2018-08-22" @default.
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• W2885158309 date "2019-01-01" @default.
• W2885158309 modified "2023-10-07" @default.
• W2885158309 title "Ultra-fast zinc ion detection in living cells and zebrafish by a light-up fluorescent probe" @default.
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• W2885158309 doi "https://doi.org/10.1016/j.saa.2018.08.025" @default.
• W2885158309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30121474" @default.
• W2885158309 hasPublicationYear "2019" @default.
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