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• W2885163547 abstract "Aim: Efficacy/safety of first-line axitinib in Asian patients with metastatic renal cell carcinoma. Methods: Patients were assigned (2:1) to 5-mg axitinib (n = 48) or 400-mg sorafenib (n = 24) twice daily. Primary end point was progression-free survival. Objective response rate, overall survival and adverse events were also assessed. Results: For axitinib versus sorafenib, hazard ratio for progression-free survival was 0.652 (95% CI: 0.340–1.252; p = 0.0989), objective response rate was higher (35.4 vs 16.7%; p = 0.0495), overall survival longer (hazard ratio: 0.739; 95% CI: 0.397–1.375; p = 0.1683). Palmar-plantar erythrodysesthesia (57.4%), diarrhea (55.3%), hypertension (51.1%) were commonest adverse events with axitinib; palmar-plantar erythrodysesthesia (50.0%) with sorafenib. Conclusion: Axitinib improved efficacy in Asian patients with metastatic renal cell carcinoma; adverse events were consistent with previous findings." @default.
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• W2885163547 date "2019-01-01" @default.
• W2885163547 modified "2023-10-11" @default.
• W2885163547 title "First-line axitinib versus sorafenib in Asian patients with metastatic renal cell carcinoma: exploratory subgroup analyses of Phase III data" @default.
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• W2885163547 doi "https://doi.org/10.2217/fon-2018-0442" @default.
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