Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885165714> ?p ?o ?g. }
- W2885165714 endingPage "966" @default.
- W2885165714 startingPage "957" @default.
- W2885165714 abstract "Diagnosis of visceral leishmaniasis (VL) and assessment of treatment response in human immunodeficiency virus (HIV)–coinfected patients still relies on invasive tissue aspiration. This hampers scale-up and decentralization of care in resource-limited settings. Noninvasive diagnostics are urgently needed. KATEX is a frequently used latex agglutination test for Leishmania antigen in urine that has never been evaluated in HIV-coinfected individuals from Leishmania donovani–endemic areas. This was an exploratory sub-study embedded within the screening phase of a trial in highly endemic northwestern Ethiopia. All patients were HIV-positive and aspirate-confirmed VL cases. We assessed diagnostic accuracy of KATEX for VL diagnosis and as test of cure at end of treatment, using tissue aspirate parasite load as reference methods. We also described the evolution of weekly antigen levels during treatment. Most of the 87 included patients were male (84, 97%), young (median age 31 years), and had poor immune status (median cluster of differentiation type 4 count 56 cells/μL). KATEX had moderate sensitivity (84%) for VL diagnosis. KATEX had moderate sensitivity (82%) and a moderate negative predictive value (87%) but only low specificity (49%) and a low positive predictive value (40%) for the assessment of treatment outcomes. Weekly antigen levels showed characteristic patterns during treatment of patients with different initial parasite loads and treatment outcomes. Antigen detection in urine using KATEX can contribute to improved VL diagnosis in HIV-coinfected patients but has limited use for monitoring of treatment response. Better noninvasive diagnostics are needed to reduce reliance on invasive methods and thus to expand and improve clinical care for VL in resource-limited settings." @default.
- W2885165714 created "2018-08-22" @default.
- W2885165714 creator A5008098933 @default.
- W2885165714 creator A5017653431 @default.
- W2885165714 creator A5026396925 @default.
- W2885165714 creator A5031626110 @default.
- W2885165714 creator A5043241965 @default.
- W2885165714 creator A5045317610 @default.
- W2885165714 creator A5050287090 @default.
- W2885165714 creator A5056143866 @default.
- W2885165714 creator A5071258464 @default.
- W2885165714 creator A5072315520 @default.
- W2885165714 creator A5076883150 @default.
- W2885165714 creator A5084346992 @default.
- W2885165714 creator A5086570334 @default.
- W2885165714 date "2018-10-03" @default.
- W2885165714 modified "2023-10-03" @default.
- W2885165714 title "Antigen Detection in Urine for Noninvasive Diagnosis and Treatment Monitoring of Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients: An Exploratory Analysis from Ethiopia" @default.
- W2885165714 cites W1548568541 @default.
- W2885165714 cites W1587418308 @default.
- W2885165714 cites W1793853564 @default.
- W2885165714 cites W1836738156 @default.
- W2885165714 cites W1904448194 @default.
- W2885165714 cites W1913812011 @default.
- W2885165714 cites W1972502339 @default.
- W2885165714 cites W1988325671 @default.
- W2885165714 cites W2004181718 @default.
- W2885165714 cites W2046144222 @default.
- W2885165714 cites W2058324263 @default.
- W2885165714 cites W2069077979 @default.
- W2885165714 cites W2076026695 @default.
- W2885165714 cites W2083590118 @default.
- W2885165714 cites W2091117213 @default.
- W2885165714 cites W2104031604 @default.
- W2885165714 cites W2106601683 @default.
- W2885165714 cites W2112959592 @default.
- W2885165714 cites W2115719503 @default.
- W2885165714 cites W2120519324 @default.
- W2885165714 cites W2128105316 @default.
- W2885165714 cites W2129359359 @default.
- W2885165714 cites W2137286214 @default.
- W2885165714 cites W2149699141 @default.
- W2885165714 cites W2152223750 @default.
- W2885165714 cites W2153326666 @default.
- W2885165714 cites W2156382913 @default.
- W2885165714 cites W2170052929 @default.
- W2885165714 cites W2298597695 @default.
- W2885165714 cites W2308544692 @default.
- W2885165714 cites W2528151722 @default.
- W2885165714 cites W2542648267 @default.
- W2885165714 cites W327649199 @default.
- W2885165714 cites W4240133843 @default.
- W2885165714 doi "https://doi.org/10.4269/ajtmh.18-0042" @default.
- W2885165714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6159592" @default.
- W2885165714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30084342" @default.
- W2885165714 hasPublicationYear "2018" @default.
- W2885165714 type Work @default.
- W2885165714 sameAs 2885165714 @default.
- W2885165714 citedByCount "11" @default.
- W2885165714 countsByYear W28851657142019 @default.
- W2885165714 countsByYear W28851657142020 @default.
- W2885165714 countsByYear W28851657142021 @default.
- W2885165714 countsByYear W28851657142022 @default.
- W2885165714 crossrefType "journal-article" @default.
- W2885165714 hasAuthorship W2885165714A5008098933 @default.
- W2885165714 hasAuthorship W2885165714A5017653431 @default.
- W2885165714 hasAuthorship W2885165714A5026396925 @default.
- W2885165714 hasAuthorship W2885165714A5031626110 @default.
- W2885165714 hasAuthorship W2885165714A5043241965 @default.
- W2885165714 hasAuthorship W2885165714A5045317610 @default.
- W2885165714 hasAuthorship W2885165714A5050287090 @default.
- W2885165714 hasAuthorship W2885165714A5056143866 @default.
- W2885165714 hasAuthorship W2885165714A5071258464 @default.
- W2885165714 hasAuthorship W2885165714A5072315520 @default.
- W2885165714 hasAuthorship W2885165714A5076883150 @default.
- W2885165714 hasAuthorship W2885165714A5084346992 @default.
- W2885165714 hasAuthorship W2885165714A5086570334 @default.
- W2885165714 hasBestOaLocation W28851657141 @default.
- W2885165714 hasConcept C126322002 @default.
- W2885165714 hasConcept C147483822 @default.
- W2885165714 hasConcept C203014093 @default.
- W2885165714 hasConcept C2776555147 @default.
- W2885165714 hasConcept C2777813720 @default.
- W2885165714 hasConcept C2778048844 @default.
- W2885165714 hasConcept C2778689377 @default.
- W2885165714 hasConcept C2780026642 @default.
- W2885165714 hasConcept C2780261877 @default.
- W2885165714 hasConcept C3013748606 @default.
- W2885165714 hasConcept C71924100 @default.
- W2885165714 hasConcept C90924648 @default.
- W2885165714 hasConceptScore W2885165714C126322002 @default.
- W2885165714 hasConceptScore W2885165714C147483822 @default.
- W2885165714 hasConceptScore W2885165714C203014093 @default.
- W2885165714 hasConceptScore W2885165714C2776555147 @default.
- W2885165714 hasConceptScore W2885165714C2777813720 @default.
- W2885165714 hasConceptScore W2885165714C2778048844 @default.
- W2885165714 hasConceptScore W2885165714C2778689377 @default.
- W2885165714 hasConceptScore W2885165714C2780026642 @default.