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• W2885177487 abstract "Four new peptaibiotics, acremotins A–D (1–4) featuring three α,α-dialkylated amino acid–imino acid motifs and an unreduced C-terminal residue, along with the known peptaibiotic XR586 (5) were isolated from the solid cultures of the soil-derived fungus Acremonium persicinum SC0105. Their primary structures were characterized by detailed analysis of the HRESIMS/MS fragmentation pattern combined with comprehensive interpretation of the 1D and 2D NMR spectroscopic data. The absolute configurations of amino acid residues were determined by the advanced Marfey’s method. Sequence alignment result shows that 1–4 are closely related to zervamicin IIB and emerimicin IIA, thus belong to peptaibiotic subfamily-3 (SF3). The three-dimensional (3D) structure of 4 was established by theoretical conformational analysis using the ab initio density functional theory (DFT) method, which, together with the CD spectrum, indicated an amphiphilic and helical structure for 4. 1–5 actively inhibited the growth of gram-positive bacterial pathogens, and amongst them 4 was the most potent compound showing MIC of 12.5 and 6.25 µg/ml against S. aureu and MRSA strains, respectively. 1–5 were also cytotoxic against three human cancer cell lines with IC50 ranging from 1.2 to 21.6 μM." @default.
• W2885177487 created "2018-08-22" @default.
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• W2885177487 date "2018-08-08" @default.
• W2885177487 modified "2023-10-16" @default.
• W2885177487 title "Acremotins A–D, peptaibiotics produced by the soil-derived fungus Acremonium persicinum SC0105" @default.
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• W2885177487 doi "https://doi.org/10.1038/s41429-018-0086-3" @default.
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