Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885183722> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2885183722 abstract "Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer. We investigated the clinical significance of TLS in ovarian cancer. Methods: 28 patients who were diagnosed with high-grade serous ovarian cancer and treated surgically in our hospital were selected from microarray dataset (KOV-75; GSE39204/55512). We evaluated TLS, tumor-infiltrating lymphocyte (TIL) subsets (CD4+ T cell, CD8+ T cell, CD20+ B cell, CD38+ plasma cell), and the correlation between expression of CXCL13 and TIL subsets by immunohistochemical staining. We analyzed the correlation between gene expression of CXCL13 and the survival time of the patients (pts) by using KOV-75 and the cancer genome atlas (TCGA) datasets. Results: Immunohistochemical staining revealed that TLS were detected in 64% (18 pts) of ovarian cancer patients, and the numbers of tumor-infiltrating CD8+ T cells, CD20+ B cells and CD38+ plasma cells were significantly higher in cases with TLS (p Conclusion: CXCL13 contributes to better prognosis in ovarian cancer patients by inducing TLS and various subsets of TIL. Induction of CXCL13 might be a new therapeutic target for ovarian cancer patients. Citation Format: Masayo Ukita, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, Masaki Mandai. Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1021." @default.
- W2885183722 created "2018-08-22" @default.
- W2885183722 creator A5011585763 @default.
- W2885183722 creator A5022396882 @default.
- W2885183722 creator A5023191265 @default.
- W2885183722 creator A5028817103 @default.
- W2885183722 creator A5051800836 @default.
- W2885183722 creator A5088883992 @default.
- W2885183722 date "2018-07-01" @default.
- W2885183722 modified "2023-09-25" @default.
- W2885183722 title "Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer" @default.
- W2885183722 doi "https://doi.org/10.1158/1538-7445.am2018-1021" @default.
- W2885183722 hasPublicationYear "2018" @default.
- W2885183722 type Work @default.
- W2885183722 sameAs 2885183722 @default.
- W2885183722 citedByCount "0" @default.
- W2885183722 crossrefType "proceedings-article" @default.
- W2885183722 hasAuthorship W2885183722A5011585763 @default.
- W2885183722 hasAuthorship W2885183722A5022396882 @default.
- W2885183722 hasAuthorship W2885183722A5023191265 @default.
- W2885183722 hasAuthorship W2885183722A5028817103 @default.
- W2885183722 hasAuthorship W2885183722A5051800836 @default.
- W2885183722 hasAuthorship W2885183722A5088883992 @default.
- W2885183722 hasBestOaLocation W28851837221 @default.
- W2885183722 hasConcept C121608353 @default.
- W2885183722 hasConcept C126322002 @default.
- W2885183722 hasConcept C12823836 @default.
- W2885183722 hasConcept C13373296 @default.
- W2885183722 hasConcept C142724271 @default.
- W2885183722 hasConcept C143998085 @default.
- W2885183722 hasConcept C159654299 @default.
- W2885183722 hasConcept C18031839 @default.
- W2885183722 hasConcept C193270364 @default.
- W2885183722 hasConcept C203014093 @default.
- W2885183722 hasConcept C204232928 @default.
- W2885183722 hasConcept C2776914184 @default.
- W2885183722 hasConcept C2777701055 @default.
- W2885183722 hasConcept C2778326572 @default.
- W2885183722 hasConcept C2778453870 @default.
- W2885183722 hasConcept C2780427987 @default.
- W2885183722 hasConcept C502942594 @default.
- W2885183722 hasConcept C71924100 @default.
- W2885183722 hasConcept C75877943 @default.
- W2885183722 hasConcept C96926380 @default.
- W2885183722 hasConceptScore W2885183722C121608353 @default.
- W2885183722 hasConceptScore W2885183722C126322002 @default.
- W2885183722 hasConceptScore W2885183722C12823836 @default.
- W2885183722 hasConceptScore W2885183722C13373296 @default.
- W2885183722 hasConceptScore W2885183722C142724271 @default.
- W2885183722 hasConceptScore W2885183722C143998085 @default.
- W2885183722 hasConceptScore W2885183722C159654299 @default.
- W2885183722 hasConceptScore W2885183722C18031839 @default.
- W2885183722 hasConceptScore W2885183722C193270364 @default.
- W2885183722 hasConceptScore W2885183722C203014093 @default.
- W2885183722 hasConceptScore W2885183722C204232928 @default.
- W2885183722 hasConceptScore W2885183722C2776914184 @default.
- W2885183722 hasConceptScore W2885183722C2777701055 @default.
- W2885183722 hasConceptScore W2885183722C2778326572 @default.
- W2885183722 hasConceptScore W2885183722C2778453870 @default.
- W2885183722 hasConceptScore W2885183722C2780427987 @default.
- W2885183722 hasConceptScore W2885183722C502942594 @default.
- W2885183722 hasConceptScore W2885183722C71924100 @default.
- W2885183722 hasConceptScore W2885183722C75877943 @default.
- W2885183722 hasConceptScore W2885183722C96926380 @default.
- W2885183722 hasLocation W28851837221 @default.
- W2885183722 hasOpenAccess W2885183722 @default.
- W2885183722 hasPrimaryLocation W28851837221 @default.
- W2885183722 hasRelatedWork W1986919315 @default.
- W2885183722 hasRelatedWork W2097820058 @default.
- W2885183722 hasRelatedWork W2491258415 @default.
- W2885183722 hasRelatedWork W2591611564 @default.
- W2885183722 hasRelatedWork W2788602025 @default.
- W2885183722 hasRelatedWork W2885183722 @default.
- W2885183722 hasRelatedWork W2917299770 @default.
- W2885183722 hasRelatedWork W3148060325 @default.
- W2885183722 hasRelatedWork W3211204931 @default.
- W2885183722 hasRelatedWork W4280519874 @default.
- W2885183722 isParatext "false" @default.
- W2885183722 isRetracted "false" @default.
- W2885183722 magId "2885183722" @default.
- W2885183722 workType "article" @default.