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- W2885192103 abstract "Abstract Near‐infrared emissive (NIR) porphyrin‐implanted carbon nanodots (PCNDs or MPCNDs) are prepared by selectively carbonization of free base or metal complexes [M = Zn(II) or Mn(III)] of tetra‐( meso ‐aminophenyl)porphyrin in the presence of citric acid. The as‐prepared nanodots exhibit spontaneously NIR emission, small size, good aqueous dispersibility, and favorable biocompatibility characteristic of both porphyrins and pristine carbon nanodots. The subcellular localization experiment of nanodots indicates a lysosome‐targeting feature. And the in vitro photodynamic therapy (PDT) results on HeLa cells indicate the nanodots alone have no adverse effect on tumor cells, but display remarkable photodynamic efficacy upon irradiation. Moreover, MnPCNDs containing paramagnetic Mn(III) ions, which possesses good biocompatibility, NIR luminescence, and magnetic resonance imaging and efficient singlet oxygen production, are further studied in magnetic resonance imaging‐guided photodynamic therapy in vivo." @default.
- W2885192103 created "2018-08-22" @default.
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- W2885192103 date "2018-08-02" @default.
- W2885192103 modified "2023-10-16" @default.
- W2885192103 title "Red/Near-Infrared Emissive Metalloporphyrin-Based Nanodots for Magnetic Resonance Imaging-Guided Photodynamic Therapy In Vivo" @default.
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- W2885192103 doi "https://doi.org/10.1002/ppsc.201800208" @default.
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