FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885192247> ?p ?o ?g. }

• W2885192247 endingPage "1771" @default.
• W2885192247 startingPage "1765" @default.
• W2885192247 abstract "This study was aimed to investigate whether ibuprofen could alter the P-glycoprotein expression and function under Alzheimer's Disease condition and whether this alteration was induced by the inhibition of inflammatory reaction. APP/PS1 mice were used as AD model mice and ibuprofen-treated AD mice were given ibuprofen for 5 months. Then, Abcb1a/1b mRNA levels and P-gp expression were evaluated by qRT-PCR and western blot. Abcb1 mRNA levels were significantly reduced in AD mice compared to control mice, and it could be restored by ibuprofen treatment. Meanwhile, P-gp expression result showed a similar trend. Aβ plaques in cerebral cortices and hippocampus were investigated via immunohistochemical, and the results revealed that Aβ plaques were reduced in ibuprofen-treated AD mice compared with the AD mice, indicated that P-gp function may be recovered by ibuprofen treatment. qRT-PCR and ELISA were used to determined TNF-α, IL-1β, IL-6 and NF-κB levels. The results demonstrated that TNF-α, IL-1β mRNA levels and NF-κB expression were all significantly upregulated in AD mice in comparison with the control mice, and ibuprofen treatment could suppress the increase of inflammatory factors. In conclusion, the P-gp expression and function were suppressed in AD condition by activating inflammatory reaction, and then causing the Aβ efflux decreased. However, upregulating P-gp could increase the Aβ efflux in further to treat AD via inhibiting the inflammatory factors expression." @default.
• W2885192247 created "2018-08-22" @default.
• W2885192247 creator A5000334611 @default.
• W2885192247 creator A5002735960 @default.
• W2885192247 creator A5019859894 @default.
• W2885192247 creator A5020284975 @default.
• W2885192247 creator A5040399801 @default.
• W2885192247 creator A5066499149 @default.
• W2885192247 creator A5070961992 @default.
• W2885192247 creator A5071812768 @default.
• W2885192247 creator A5089132442 @default.
• W2885192247 date "2018-11-01" @default.
• W2885192247 modified "2023-10-02" @default.
• W2885192247 title "A new approach for Alzheimer's disease treatment through P-gp regulation via ibuprofen" @default.
• W2885192247 cites W1503139355 @default.
• W2885192247 cites W1592789336 @default.
• W2885192247 cites W1803013685 @default.
• W2885192247 cites W1900715746 @default.
• W2885192247 cites W1920113691 @default.
• W2885192247 cites W1931867099 @default.
• W2885192247 cites W1963640795 @default.
• W2885192247 cites W2001148507 @default.
• W2885192247 cites W2008591852 @default.
• W2885192247 cites W2014084035 @default.
• W2885192247 cites W2029524925 @default.
• W2885192247 cites W2034139110 @default.
• W2885192247 cites W2055092854 @default.
• W2885192247 cites W2057765028 @default.
• W2885192247 cites W2062699557 @default.
• W2885192247 cites W2067267561 @default.
• W2885192247 cites W2068561160 @default.
• W2885192247 cites W2091805091 @default.
• W2885192247 cites W2119324011 @default.
• W2885192247 cites W2131047041 @default.
• W2885192247 cites W2137497029 @default.
• W2885192247 cites W2139563079 @default.
• W2885192247 cites W2140131793 @default.
• W2885192247 cites W2151663689 @default.
• W2885192247 cites W2167527439 @default.
• W2885192247 cites W2179970487 @default.
• W2885192247 cites W2240073326 @default.
• W2885192247 cites W2269013989 @default.
• W2885192247 cites W2282264810 @default.
• W2885192247 cites W2300070246 @default.
• W2885192247 cites W2513446203 @default.
• W2885192247 cites W2560415430 @default.
• W2885192247 cites W2739431564 @default.
• W2885192247 cites W2764004497 @default.
• W2885192247 cites W2770210536 @default.
• W2885192247 cites W2777277663 @default.
• W2885192247 cites W2783177814 @default.
• W2885192247 cites W2811294256 @default.
• W2885192247 cites W4210981518 @default.
• W2885192247 doi "https://doi.org/10.1016/j.prp.2018.08.011" @default.
• W2885192247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30139557" @default.
• W2885192247 hasPublicationYear "2018" @default.
• W2885192247 type Work @default.
• W2885192247 sameAs 2885192247 @default.
• W2885192247 citedByCount "14" @default.
• W2885192247 countsByYear W28851922472020 @default.
• W2885192247 countsByYear W28851922472021 @default.
• W2885192247 countsByYear W28851922472023 @default.
• W2885192247 crossrefType "journal-article" @default.
• W2885192247 hasAuthorship W2885192247A5000334611 @default.
• W2885192247 hasAuthorship W2885192247A5002735960 @default.
• W2885192247 hasAuthorship W2885192247A5019859894 @default.
• W2885192247 hasAuthorship W2885192247A5020284975 @default.
• W2885192247 hasAuthorship W2885192247A5040399801 @default.
• W2885192247 hasAuthorship W2885192247A5066499149 @default.
• W2885192247 hasAuthorship W2885192247A5070961992 @default.
• W2885192247 hasAuthorship W2885192247A5071812768 @default.
• W2885192247 hasAuthorship W2885192247A5089132442 @default.
• W2885192247 hasConcept C104317684 @default.
• W2885192247 hasConcept C105580179 @default.
• W2885192247 hasConcept C126322002 @default.
• W2885192247 hasConcept C127561419 @default.
• W2885192247 hasConcept C133936738 @default.
• W2885192247 hasConcept C134018914 @default.
• W2885192247 hasConcept C185592680 @default.
• W2885192247 hasConcept C200082930 @default.
• W2885192247 hasConcept C204232928 @default.
• W2885192247 hasConcept C2776415932 @default.
• W2885192247 hasConcept C2778707650 @default.
• W2885192247 hasConcept C2779944601 @default.
• W2885192247 hasConcept C2781161787 @default.
• W2885192247 hasConcept C501593827 @default.
• W2885192247 hasConcept C55493867 @default.
• W2885192247 hasConcept C71924100 @default.
• W2885192247 hasConcept C85265743 @default.
• W2885192247 hasConcept C98274493 @default.
• W2885192247 hasConceptScore W2885192247C104317684 @default.
• W2885192247 hasConceptScore W2885192247C105580179 @default.
• W2885192247 hasConceptScore W2885192247C126322002 @default.
• W2885192247 hasConceptScore W2885192247C127561419 @default.
• W2885192247 hasConceptScore W2885192247C133936738 @default.
• W2885192247 hasConceptScore W2885192247C134018914 @default.
• W2885192247 hasConceptScore W2885192247C185592680 @default.
• W2885192247 hasConceptScore W2885192247C200082930 @default.

• next