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- W2885192457 abstract "Background—Recent studies have suggested that testosterone has a protective effect in the arterial vascular system. However, little is known about the molecular aspects of the mechanism(s) involved in these processes. The aim of the present study was to investigate the effect of testosterone on neointimal plaque development and on the expression of the vascular androgen receptor. Methods and Results—Neointimal plaque formation was induced by endothelial denudation in the aortas of male New Zealand White rabbits. Aortic ring segments were cultured for 21 days after endothelial denudation. Testosterone was applied to the culture medium in different doses. Compared with the non–hormone-treated control group, a significant inhibition of neointimal plaque development (expressed as the intima/media ratio) was found at testosterone concentrations of 10 ng/mL (P=0.037) and 100 ng/mL (P=0.012; intima/media ratios: median of controls, 0.25; median of 10 ng/mL testosterone group, 0.15; median of 100 ng/mL testostero..." @default.
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- W2885192457 date "2001-03-13" @default.
- W2885192457 modified "2023-09-23" @default.
- W2885192457 title "Effect of Testosterone on Plaque Development and Androgen Receptor Expression in the Arterial Vessel Wall" @default.
- W2885192457 hasPublicationYear "2001" @default.
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