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- W2885194162 abstract "Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding of cancer signalling networks has led to the development of novel strategies to tackle resistance both in the first-line and salvage therapy settings. In this review, we provide a brief overview of the major classes of resistance mechanisms to targeted therapy, including signalling reprogramming and tumour evolution; our discussion also focuses on the use of different forms of polytherapies (such as inhibitor combinations, multi-target kinase inhibitors and HSP90 inhibitors) as a means of combating resistance. The promise and challenges facing each of these polytherapies are elaborated with a perspective on how to effectively deploy such therapies in patients. We highlight efforts to harness computational approaches to predict effective polytherapies and the emerging view that exceptional responders may hold the key to better understanding drug resistance. This review underscores the importance of polytherapies as an effective means of targeting resistance signalling networks and achieving durable clinical responses in the era of personalised cancer medicine." @default.
- W2885194162 created "2018-08-22" @default.
- W2885194162 creator A5006145069 @default.
- W2885194162 creator A5032930336 @default.
- W2885194162 date "2018-08-02" @default.
- W2885194162 modified "2023-10-18" @default.
- W2885194162 title "Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance" @default.
- W2885194162 cites W1157613785 @default.
- W2885194162 cites W1554180547 @default.
- W2885194162 cites W1835539092 @default.
- W2885194162 cites W1943756471 @default.
- W2885194162 cites W1976422747 @default.
- W2885194162 cites W1980497534 @default.
- W2885194162 cites W1988303870 @default.
- W2885194162 cites W1988825409 @default.
- W2885194162 cites W1992880310 @default.
- W2885194162 cites W1992909271 @default.
- W2885194162 cites W1993675254 @default.
- W2885194162 cites W1995380559 @default.
- W2885194162 cites W1997476230 @default.
- W2885194162 cites W2004295816 @default.
- W2885194162 cites W2014445008 @default.
- W2885194162 cites W2014582878 @default.
- W2885194162 cites W2015616444 @default.
- W2885194162 cites W2020372547 @default.
- W2885194162 cites W2021227263 @default.
- W2885194162 cites W2028415754 @default.
- W2885194162 cites W2029243355 @default.
- W2885194162 cites W2043058822 @default.
- W2885194162 cites W2043696829 @default.
- W2885194162 cites W2043880180 @default.
- W2885194162 cites W2045953361 @default.
- W2885194162 cites W2047123780 @default.
- W2885194162 cites W2060902443 @default.
- W2885194162 cites W2062967876 @default.
- W2885194162 cites W2066128027 @default.
- W2885194162 cites W2072810564 @default.
- W2885194162 cites W2073444773 @default.
- W2885194162 cites W2077804275 @default.
- W2885194162 cites W2079012552 @default.
- W2885194162 cites W2079281935 @default.
- W2885194162 cites W2088891952 @default.
- W2885194162 cites W2088942787 @default.
- W2885194162 cites W2089290845 @default.
- W2885194162 cites W2094902224 @default.
- W2885194162 cites W2096156234 @default.
- W2885194162 cites W2096387850 @default.
- W2885194162 cites W2097799776 @default.
- W2885194162 cites W2097946794 @default.
- W2885194162 cites W2098736886 @default.
- W2885194162 cites W2100541925 @default.
- W2885194162 cites W2105660237 @default.
- W2885194162 cites W2111490539 @default.
- W2885194162 cites W2114032749 @default.
- W2885194162 cites W2115045760 @default.
- W2885194162 cites W2116978375 @default.
- W2885194162 cites W2118952409 @default.
- W2885194162 cites W2121280521 @default.
- W2885194162 cites W2122995608 @default.
- W2885194162 cites W2127975859 @default.
- W2885194162 cites W2128542677 @default.
- W2885194162 cites W2131174104 @default.
- W2885194162 cites W2132230893 @default.
- W2885194162 cites W2136474966 @default.
- W2885194162 cites W2143939343 @default.
- W2885194162 cites W2147984622 @default.
- W2885194162 cites W2149662085 @default.
- W2885194162 cites W2153898589 @default.
- W2885194162 cites W2159587676 @default.
- W2885194162 cites W2163840470 @default.
- W2885194162 cites W2164696589 @default.
- W2885194162 cites W2165575701 @default.
- W2885194162 cites W2194401605 @default.
- W2885194162 cites W2215284129 @default.
- W2885194162 cites W2226907294 @default.
- W2885194162 cites W2259572413 @default.
- W2885194162 cites W2262646263 @default.
- W2885194162 cites W2272802268 @default.
- W2885194162 cites W2279253506 @default.
- W2885194162 cites W2292329947 @default.
- W2885194162 cites W2523813985 @default.
- W2885194162 cites W2539053995 @default.
- W2885194162 cites W2596319736 @default.
- W2885194162 cites W2597646117 @default.
- W2885194162 cites W2601222128 @default.
- W2885194162 cites W2611044189 @default.
- W2885194162 cites W2621895366 @default.
- W2885194162 cites W2764184942 @default.
- W2885194162 cites W2765239123 @default.
- W2885194162 cites W2766316939 @default.
- W2885194162 cites W2790982990 @default.
- W2885194162 cites W2952106488 @default.
- W2885194162 cites W4234654105 @default.
- W2885194162 cites W781001238 @default.
- W2885194162 doi "https://doi.org/10.1042/ebc20180016" @default.
- W2885194162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6204552" @default.
- W2885194162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30072489" @default.
- W2885194162 hasPublicationYear "2018" @default.