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• W2885194838 abstract "Mouse p202 is a disease locus for lupus and a dominant-negative inhibitor of AIM2 inflammasome activation. A human homolog of p202 has not been identified so far. Here, we report a novel transcript isoform of human IFI16-designated IFI16-β, which has a domain architecture similar to that of mouse p202. Like p202, IFI16-β contains two HIN domains, but lacks the pyrin domain. IFI16-β is ubiquitously expressed in various human tissues and cells. Its mRNA levels are also elevated in leukocytes of patients with lupus, virus-infected cells, and cells treated with interferon-β or phorbol ester. IFI16-β co-localizes with AIM2 in the cytoplasm, whereas IFI16-α is predominantly found in the nucleus. IFI16-β interacts with AIM2 to impede the formation of a functional AIM2-ASC complex. In addition, IFI16-β sequesters cytoplasmic dsDNA and renders it unavailable for AIM2 sensing. Enforced expression of IFI16-β inhibits the activation of AIM2 inflammasome, whereas knockdown of IFI16-β augments interleukin-1β secretion triggered by dsDNA but not dsRNA Thus, cytoplasm-localized IFI16-β is functionally equivalent to mouse p202 that exerts an inhibitory effect on AIM2 inflammasome." @default.
• W2885194838 created "2018-08-22" @default.
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• W2885194838 date "2018-08-13" @default.
• W2885194838 modified "2023-10-16" @default.
• W2885194838 title "Inhibition of <scp>AIM</scp> 2 inflammasome activation by a novel transcript isoform of <scp>IFI</scp> 16" @default.
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• W2885194838 doi "https://doi.org/10.15252/embr.201845737" @default.
• W2885194838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172465" @default.
• W2885194838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30104205" @default.
• W2885194838 hasPublicationYear "2018" @default.
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