Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885196612> ?p ?o ?g. }
- W2885196612 endingPage "1175" @default.
- W2885196612 startingPage "1163" @default.
- W2885196612 abstract "Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous infection. Using isogenic mutants deleted from genes encoding each or all of these three virulence factors, we investigated their role in induction of inflammatory response and in tissue invasiveness in human primary keratinocytes and reconstructed epidermis. Our results showed that flagellum, but not T2SS and T3SS, is involved in induction of a large panel of cytokine, chemokine, and antimicrobial peptide (AMP) mRNA in the infected keratinocytes. Chemokine secretion and AMP tissular production were also dependent on the presence of the bacterial flagellum. This pro-inflammatory effect was significantly reduced in keratinocytes infected in presence of anti-toll-like receptor 5 (TLR5) neutralizing antibody. Bacterial invasion of human epidermis and persistence in a mouse model of sub-cutaneous infection were dependent on the P. aeruginosa flagellum. We demonstrated that flagellum constitutes the main virulence factor of P. aeruginosa involved not only in early induction of the epidermis inflammatory response but also in bacterial invasion and cutaneous persistence. P. aeruginosa is mainly sensed by TLR5 during the early innate immune response of human primary keratinocytes." @default.
- W2885196612 created "2018-08-22" @default.
- W2885196612 creator A5003211916 @default.
- W2885196612 creator A5011536713 @default.
- W2885196612 creator A5015131799 @default.
- W2885196612 creator A5022447010 @default.
- W2885196612 creator A5033161345 @default.
- W2885196612 creator A5035641544 @default.
- W2885196612 creator A5037124332 @default.
- W2885196612 creator A5042964046 @default.
- W2885196612 creator A5046902638 @default.
- W2885196612 creator A5060126560 @default.
- W2885196612 date "2018-08-02" @default.
- W2885196612 modified "2023-10-06" @default.
- W2885196612 title "<i>Pseudomonas aeruginosa</i> flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis" @default.
- W2885196612 cites W1513392595 @default.
- W2885196612 cites W1555657499 @default.
- W2885196612 cites W1557965441 @default.
- W2885196612 cites W1571292455 @default.
- W2885196612 cites W1585504724 @default.
- W2885196612 cites W1655860314 @default.
- W2885196612 cites W1886122999 @default.
- W2885196612 cites W1903004199 @default.
- W2885196612 cites W1959671433 @default.
- W2885196612 cites W1971013220 @default.
- W2885196612 cites W1973394808 @default.
- W2885196612 cites W1973516496 @default.
- W2885196612 cites W1978623574 @default.
- W2885196612 cites W1978839325 @default.
- W2885196612 cites W1985596227 @default.
- W2885196612 cites W1996204404 @default.
- W2885196612 cites W1999088989 @default.
- W2885196612 cites W2004773897 @default.
- W2885196612 cites W2005453584 @default.
- W2885196612 cites W2006120701 @default.
- W2885196612 cites W2006850010 @default.
- W2885196612 cites W2006990207 @default.
- W2885196612 cites W2013354312 @default.
- W2885196612 cites W2014865051 @default.
- W2885196612 cites W2017266538 @default.
- W2885196612 cites W2020922034 @default.
- W2885196612 cites W2026730319 @default.
- W2885196612 cites W2037271637 @default.
- W2885196612 cites W2048165059 @default.
- W2885196612 cites W2052318993 @default.
- W2885196612 cites W2053434264 @default.
- W2885196612 cites W2054270612 @default.
- W2885196612 cites W2058246783 @default.
- W2885196612 cites W2071174017 @default.
- W2885196612 cites W2074043272 @default.
- W2885196612 cites W2075185464 @default.
- W2885196612 cites W2077049678 @default.
- W2885196612 cites W2078895028 @default.
- W2885196612 cites W2078963979 @default.
- W2885196612 cites W2079260693 @default.
- W2885196612 cites W2082389794 @default.
- W2885196612 cites W2090417696 @default.
- W2885196612 cites W2092459505 @default.
- W2885196612 cites W2101442493 @default.
- W2885196612 cites W2106026809 @default.
- W2885196612 cites W2110793294 @default.
- W2885196612 cites W2125766883 @default.
- W2885196612 cites W2127207030 @default.
- W2885196612 cites W2130599662 @default.
- W2885196612 cites W2134952168 @default.
- W2885196612 cites W2135623402 @default.
- W2885196612 cites W2140611106 @default.
- W2885196612 cites W2147164329 @default.
- W2885196612 cites W2147498477 @default.
- W2885196612 cites W2149574665 @default.
- W2885196612 cites W2151157551 @default.
- W2885196612 cites W2152240646 @default.
- W2885196612 cites W2161023884 @default.
- W2885196612 cites W2163269093 @default.
- W2885196612 cites W2164719325 @default.
- W2885196612 cites W2165767917 @default.
- W2885196612 cites W2171788936 @default.
- W2885196612 cites W2568620795 @default.
- W2885196612 cites W2767604730 @default.
- W2885196612 cites W4238026016 @default.
- W2885196612 cites W43443165 @default.
- W2885196612 doi "https://doi.org/10.1080/21505594.2018.1480830" @default.
- W2885196612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086312" @default.
- W2885196612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30070169" @default.
- W2885196612 hasPublicationYear "2018" @default.
- W2885196612 type Work @default.
- W2885196612 sameAs 2885196612 @default.
- W2885196612 citedByCount "27" @default.
- W2885196612 countsByYear W28851966122019 @default.
- W2885196612 countsByYear W28851966122020 @default.
- W2885196612 countsByYear W28851966122021 @default.
- W2885196612 countsByYear W28851966122022 @default.
- W2885196612 countsByYear W28851966122023 @default.
- W2885196612 crossrefType "journal-article" @default.
- W2885196612 hasAuthorship W2885196612A5003211916 @default.
- W2885196612 hasAuthorship W2885196612A5011536713 @default.
- W2885196612 hasAuthorship W2885196612A5015131799 @default.
- W2885196612 hasAuthorship W2885196612A5022447010 @default.