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- W2885198768 abstract "Oxidative damage and inflammation coexist in healthy human brain aging. The present study analyzes levels of protein adduction by lipid peroxidation (LP) end-products neuroketal (NKT) and malondialdehyde (MDA), as markers of protein oxidative damage, cycloxygenase-2 (COX-2) levels, as a marker of inflammation, and cytochrome P450 2J2 (CYP2J2), responsible of generation of neuroprotective products, in twelve brain regions in normal middle-aged individuals (MA) and old-aged (OA) individuals. In addition, levels of these markers were evaluated as a function of age as a continuous variable and correction for multiple comparisons. Selection of regions was based on their different vulnerability to prevalent neurodegenerative diseases in aging. Our findings show region-dependent LP end-products, COX-2 and CYP2J2 changes in the aging human brain. However, no clear relationship can be established between NKT, MDA, COX-2 and CYP2J2 levels, and regional vulnerability to neurodegeneration in old age." @default.
- W2885198768 created "2018-08-22" @default.
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- W2885198768 date "2018-10-01" @default.
- W2885198768 modified "2023-10-15" @default.
- W2885198768 title "Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging" @default.
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- W2885198768 doi "https://doi.org/10.1016/j.exger.2018.07.023" @default.
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