Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885199498> ?p ?o ?g. }
- W2885199498 endingPage "445" @default.
- W2885199498 startingPage "442" @default.
- W2885199498 abstract "Systematic evaluation of biomarkers in representative populations is needed to validate their clinical utility. In this work, we assessed the diagnostic performance of cerebrospinal fluid (CSF) neurofilament light chain (NfL) in a neurocognitive clinical setting. A total of 51 patients with different cognitive clinical syndromes and 11 cognitively normal individuals were evaluated in a memory clinic in Argentina. Clinical conditions included mild cognitive impairment (MCI, n = 12), dementia of Alzheimer’s type (DAT, n = 14), behavioral variant frontotemporal dementia (bvFTD, n = 13), and primary progressive aphasia (logopenic [n = 6], semantic [n = 2], and nonfluent [n = 4]). We quantified CSF NfL and core Alzheimer’s disease biomarkers using commercially available ELISA kits. Cortical thickness was analyzed on brain magnetic resonance imaging scans from 10 controls and 10 patients. CSF NfL was significantly increased in MCI, FTD, and DAT patients compared with controls (Kruskal–Wallis, p < .0001). Interestingly, receiver operating characteristic curve analysis showed the highest area under the curve (AUC) value when analyzing control versus bvFTD patients (AUC = 0.9441). Also, we observed a marginally significant correlation between NfL levels and left orbitofrontal cortex thickness in a small group of patients with FTD. Overall, our results further support CSF NfL as a promising biomarker in the diagnostic workup of bvFTD." @default.
- W2885199498 created "2018-08-22" @default.
- W2885199498 creator A5013104360 @default.
- W2885199498 creator A5020124739 @default.
- W2885199498 creator A5022639023 @default.
- W2885199498 creator A5022647516 @default.
- W2885199498 creator A5024648152 @default.
- W2885199498 creator A5026532385 @default.
- W2885199498 creator A5028976283 @default.
- W2885199498 creator A5058618289 @default.
- W2885199498 creator A5066984112 @default.
- W2885199498 creator A5072943236 @default.
- W2885199498 creator A5072960793 @default.
- W2885199498 creator A5080314403 @default.
- W2885199498 creator A5080318141 @default.
- W2885199498 creator A5090368346 @default.
- W2885199498 date "2018-08-10" @default.
- W2885199498 modified "2023-10-06" @default.
- W2885199498 title "Evaluation of Cerebrospinal Fluid Neurofilament Light Chain as a Routine Biomarker in a Memory Clinic" @default.
- W2885199498 cites W1833523444 @default.
- W2885199498 cites W1981844785 @default.
- W2885199498 cites W1988896658 @default.
- W2885199498 cites W2056196309 @default.
- W2885199498 cites W2065338300 @default.
- W2885199498 cites W2096418706 @default.
- W2885199498 cites W2115017507 @default.
- W2885199498 cites W2134323711 @default.
- W2885199498 cites W2141909536 @default.
- W2885199498 cites W2148907640 @default.
- W2885199498 cites W2460723165 @default.
- W2885199498 cites W2528978308 @default.
- W2885199498 cites W2552606408 @default.
- W2885199498 cites W2587397868 @default.
- W2885199498 cites W2592020490 @default.
- W2885199498 cites W2604210857 @default.
- W2885199498 cites W2615249314 @default.
- W2885199498 cites W2736509962 @default.
- W2885199498 cites W2795044348 @default.
- W2885199498 cites W2798054687 @default.
- W2885199498 cites W2802518465 @default.
- W2885199498 doi "https://doi.org/10.1093/gerona/gly179" @default.
- W2885199498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30107413" @default.
- W2885199498 hasPublicationYear "2018" @default.
- W2885199498 type Work @default.
- W2885199498 sameAs 2885199498 @default.
- W2885199498 citedByCount "17" @default.
- W2885199498 countsByYear W28851994982018 @default.
- W2885199498 countsByYear W28851994982019 @default.
- W2885199498 countsByYear W28851994982020 @default.
- W2885199498 countsByYear W28851994982021 @default.
- W2885199498 countsByYear W28851994982023 @default.
- W2885199498 crossrefType "journal-article" @default.
- W2885199498 hasAuthorship W2885199498A5013104360 @default.
- W2885199498 hasAuthorship W2885199498A5020124739 @default.
- W2885199498 hasAuthorship W2885199498A5022639023 @default.
- W2885199498 hasAuthorship W2885199498A5022647516 @default.
- W2885199498 hasAuthorship W2885199498A5024648152 @default.
- W2885199498 hasAuthorship W2885199498A5026532385 @default.
- W2885199498 hasAuthorship W2885199498A5028976283 @default.
- W2885199498 hasAuthorship W2885199498A5058618289 @default.
- W2885199498 hasAuthorship W2885199498A5066984112 @default.
- W2885199498 hasAuthorship W2885199498A5072943236 @default.
- W2885199498 hasAuthorship W2885199498A5072960793 @default.
- W2885199498 hasAuthorship W2885199498A5080314403 @default.
- W2885199498 hasAuthorship W2885199498A5080318141 @default.
- W2885199498 hasAuthorship W2885199498A5090368346 @default.
- W2885199498 hasBestOaLocation W28851994982 @default.
- W2885199498 hasConcept C118552586 @default.
- W2885199498 hasConcept C126322002 @default.
- W2885199498 hasConcept C126838900 @default.
- W2885199498 hasConcept C142724271 @default.
- W2885199498 hasConcept C143409427 @default.
- W2885199498 hasConcept C143998085 @default.
- W2885199498 hasConcept C169900460 @default.
- W2885199498 hasConcept C172467417 @default.
- W2885199498 hasConcept C185592680 @default.
- W2885199498 hasConcept C2776559556 @default.
- W2885199498 hasConcept C2776656118 @default.
- W2885199498 hasConcept C2778641062 @default.
- W2885199498 hasConcept C2779134260 @default.
- W2885199498 hasConcept C2779140760 @default.
- W2885199498 hasConcept C2779483572 @default.
- W2885199498 hasConcept C2779651940 @default.
- W2885199498 hasConcept C2781195155 @default.
- W2885199498 hasConcept C2781197716 @default.
- W2885199498 hasConcept C55493867 @default.
- W2885199498 hasConcept C58471807 @default.
- W2885199498 hasConcept C71924100 @default.
- W2885199498 hasConcept C76318530 @default.
- W2885199498 hasConcept C90924648 @default.
- W2885199498 hasConceptScore W2885199498C118552586 @default.
- W2885199498 hasConceptScore W2885199498C126322002 @default.
- W2885199498 hasConceptScore W2885199498C126838900 @default.
- W2885199498 hasConceptScore W2885199498C142724271 @default.
- W2885199498 hasConceptScore W2885199498C143409427 @default.
- W2885199498 hasConceptScore W2885199498C143998085 @default.
- W2885199498 hasConceptScore W2885199498C169900460 @default.
- W2885199498 hasConceptScore W2885199498C172467417 @default.