Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885202647> ?p ?o ?g. }
- W2885202647 abstract "Glycogen synthase kinase‐3 (GSK‐3) is a highly conserved negative regulator of receptor tyrosine kinase, cytokine, and Wnt signaling pathways. Stimulation of these pathways inhibits GSK‐3 to modulate diverse downstream effectors that include transcription factors, nutrient sensors, glycogen synthesis, mitochondrial function, circadian rhythm, and cell fate. GSK‐3 also regulates alternative splicing in response to T‐cell receptor activation, and recent phosphoproteomic studies have revealed that multiple splicing factors and regulators of RNA biosynthesis are phosphorylated in a GSK‐3‐dependent manner. Furthermore, inhibition of GSK‐3 alters the splicing of hundreds of mRNAs, indicating a broad role for GSK‐3 in the regulation of RNA processing. GSK‐3‐regulated phosphoproteins include SF3B1, SRSF2, PSF, RBM8A, nucleophosmin 1 (NPM1), and PHF6, many of which are mutated in leukemia and myelodysplasia. As GSK‐3 is inhibited by pathways that are pathologically activated in leukemia and loss of Gsk3 in hematopoietic cells causes a severe myelodysplastic neoplasm in mice, these findings strongly implicate GSK‐3 as a critical regulator of mRNA processing in normal and malignant hematopoiesis. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications" @default.
- W2885202647 created "2018-08-22" @default.
- W2885202647 creator A5068876839 @default.
- W2885202647 creator A5077385497 @default.
- W2885202647 date "2018-08-17" @default.
- W2885202647 modified "2023-10-12" @default.
- W2885202647 title "Glycogen synthase kinase‐3 and alternative splicing" @default.
- W2885202647 cites W1255676896 @default.
- W2885202647 cites W1501596399 @default.
- W2885202647 cites W1506037097 @default.
- W2885202647 cites W1508696424 @default.
- W2885202647 cites W15248648 @default.
- W2885202647 cites W1527383154 @default.
- W2885202647 cites W1569244981 @default.
- W2885202647 cites W1591518654 @default.
- W2885202647 cites W1601657500 @default.
- W2885202647 cites W1802578251 @default.
- W2885202647 cites W1821422107 @default.
- W2885202647 cites W1857109061 @default.
- W2885202647 cites W1963561816 @default.
- W2885202647 cites W1968904120 @default.
- W2885202647 cites W1972083681 @default.
- W2885202647 cites W1972343960 @default.
- W2885202647 cites W1973754120 @default.
- W2885202647 cites W1973992999 @default.
- W2885202647 cites W1974760231 @default.
- W2885202647 cites W1978714931 @default.
- W2885202647 cites W1978995691 @default.
- W2885202647 cites W1980220309 @default.
- W2885202647 cites W1980261795 @default.
- W2885202647 cites W1980456750 @default.
- W2885202647 cites W1981721614 @default.
- W2885202647 cites W1986766871 @default.
- W2885202647 cites W1989136001 @default.
- W2885202647 cites W1989445638 @default.
- W2885202647 cites W1989930884 @default.
- W2885202647 cites W1990848127 @default.
- W2885202647 cites W1996753824 @default.
- W2885202647 cites W1997184614 @default.
- W2885202647 cites W1997565067 @default.
- W2885202647 cites W1998929090 @default.
- W2885202647 cites W1999876234 @default.
- W2885202647 cites W2001973462 @default.
- W2885202647 cites W2002792135 @default.
- W2885202647 cites W2005806113 @default.
- W2885202647 cites W2005844899 @default.
- W2885202647 cites W2010155516 @default.
- W2885202647 cites W2010337187 @default.
- W2885202647 cites W2011920499 @default.
- W2885202647 cites W2011965408 @default.
- W2885202647 cites W2012962381 @default.
- W2885202647 cites W2014415555 @default.
- W2885202647 cites W2018553282 @default.
- W2885202647 cites W2019041110 @default.
- W2885202647 cites W2019043753 @default.
- W2885202647 cites W2019450815 @default.
- W2885202647 cites W2021748681 @default.
- W2885202647 cites W2022309233 @default.
- W2885202647 cites W2022495797 @default.
- W2885202647 cites W2025391163 @default.
- W2885202647 cites W2025565849 @default.
- W2885202647 cites W2025777952 @default.
- W2885202647 cites W2027804420 @default.
- W2885202647 cites W2029728793 @default.
- W2885202647 cites W2029979788 @default.
- W2885202647 cites W2030056549 @default.
- W2885202647 cites W2031321792 @default.
- W2885202647 cites W2031890346 @default.
- W2885202647 cites W2038358516 @default.
- W2885202647 cites W2038504801 @default.
- W2885202647 cites W2038617876 @default.
- W2885202647 cites W2039842713 @default.
- W2885202647 cites W2040373032 @default.
- W2885202647 cites W2041627592 @default.
- W2885202647 cites W2047176075 @default.
- W2885202647 cites W2051640170 @default.
- W2885202647 cites W2052505035 @default.
- W2885202647 cites W2053265248 @default.
- W2885202647 cites W2053692735 @default.
- W2885202647 cites W2055303877 @default.
- W2885202647 cites W2056909568 @default.
- W2885202647 cites W2057368600 @default.
- W2885202647 cites W2057403210 @default.
- W2885202647 cites W2058138221 @default.
- W2885202647 cites W2058755719 @default.
- W2885202647 cites W2060300682 @default.
- W2885202647 cites W2064813555 @default.
- W2885202647 cites W2066766199 @default.
- W2885202647 cites W2068180510 @default.
- W2885202647 cites W2072319692 @default.
- W2885202647 cites W2073625610 @default.
- W2885202647 cites W2073889874 @default.
- W2885202647 cites W2081870738 @default.
- W2885202647 cites W2082429191 @default.
- W2885202647 cites W2083308747 @default.
- W2885202647 cites W2084043967 @default.
- W2885202647 cites W2091726040 @default.
- W2885202647 cites W2095331513 @default.
- W2885202647 cites W2096179701 @default.
- W2885202647 cites W2096674266 @default.