Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885204311> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2885204311 abstract "Objective— Activation and proliferation of vascular smooth muscle cells (VSMCs) occur in the venous neointima of vein grafts. VSMCs in a grafted vein are subjected to mechanical stretch; our goal is to understand the essential mechanical stretch-regulated signals that influence VSMCs during neointimal formation in vein grafts. Methods and Results— In cultured vein VSMCs, mechanical stretch induces proliferation and upregulation of both IGF-1 and IGF-1R. Stretch of VSMCs sustained tyrosine phosphorylation of both IGF-1R and its substrate, IRS-1; these responses were related to mechanical stretch-induced activation of Src and autocrine IGF-1 production. Mechanical stretch-activated IGF-1R is functional because there is a prolonged activation of IRS-1-associated phosphatidylinositol-3 kinase (PI3K). When we knocked out IGF-1R, the mechanical stretch-induced increase in VSMC proliferation was blocked. To link mechanical stretch-activated IGF-1R cell signaling to venous VSMC proliferation in vivo, we also stud..." @default.
- W2885204311 created "2018-08-22" @default.
- W2885204311 creator A5003438023 @default.
- W2885204311 creator A5057047563 @default.
- W2885204311 date "2007-08-01" @default.
- W2885204311 modified "2023-09-23" @default.
- W2885204311 title "Mechanical Stretch Simulates Proliferation of Venous Smooth Muscle Cells Through Activation of the Insulin-Like Growth Factor-1 Receptor" @default.
- W2885204311 hasPublicationYear "2007" @default.
- W2885204311 type Work @default.
- W2885204311 sameAs 2885204311 @default.
- W2885204311 citedByCount "0" @default.
- W2885204311 crossrefType "journal-article" @default.
- W2885204311 hasAuthorship W2885204311A5003438023 @default.
- W2885204311 hasAuthorship W2885204311A5057047563 @default.
- W2885204311 hasConcept C104317684 @default.
- W2885204311 hasConcept C11960822 @default.
- W2885204311 hasConcept C126322002 @default.
- W2885204311 hasConcept C127561419 @default.
- W2885204311 hasConcept C128240485 @default.
- W2885204311 hasConcept C134018914 @default.
- W2885204311 hasConcept C170493617 @default.
- W2885204311 hasConcept C185592680 @default.
- W2885204311 hasConcept C2775960820 @default.
- W2885204311 hasConcept C2777339539 @default.
- W2885204311 hasConcept C2777553839 @default.
- W2885204311 hasConcept C2778283817 @default.
- W2885204311 hasConcept C2778583881 @default.
- W2885204311 hasConcept C2779395532 @default.
- W2885204311 hasConcept C2780689927 @default.
- W2885204311 hasConcept C2992686903 @default.
- W2885204311 hasConcept C55493867 @default.
- W2885204311 hasConcept C62112901 @default.
- W2885204311 hasConcept C71924100 @default.
- W2885204311 hasConcept C86803240 @default.
- W2885204311 hasConcept C95444343 @default.
- W2885204311 hasConceptScore W2885204311C104317684 @default.
- W2885204311 hasConceptScore W2885204311C11960822 @default.
- W2885204311 hasConceptScore W2885204311C126322002 @default.
- W2885204311 hasConceptScore W2885204311C127561419 @default.
- W2885204311 hasConceptScore W2885204311C128240485 @default.
- W2885204311 hasConceptScore W2885204311C134018914 @default.
- W2885204311 hasConceptScore W2885204311C170493617 @default.
- W2885204311 hasConceptScore W2885204311C185592680 @default.
- W2885204311 hasConceptScore W2885204311C2775960820 @default.
- W2885204311 hasConceptScore W2885204311C2777339539 @default.
- W2885204311 hasConceptScore W2885204311C2777553839 @default.
- W2885204311 hasConceptScore W2885204311C2778283817 @default.
- W2885204311 hasConceptScore W2885204311C2778583881 @default.
- W2885204311 hasConceptScore W2885204311C2779395532 @default.
- W2885204311 hasConceptScore W2885204311C2780689927 @default.
- W2885204311 hasConceptScore W2885204311C2992686903 @default.
- W2885204311 hasConceptScore W2885204311C55493867 @default.
- W2885204311 hasConceptScore W2885204311C62112901 @default.
- W2885204311 hasConceptScore W2885204311C71924100 @default.
- W2885204311 hasConceptScore W2885204311C86803240 @default.
- W2885204311 hasConceptScore W2885204311C95444343 @default.
- W2885204311 hasLocation W28852043111 @default.
- W2885204311 hasOpenAccess W2885204311 @default.
- W2885204311 hasPrimaryLocation W28852043111 @default.
- W2885204311 hasRelatedWork W1746540096 @default.
- W2885204311 hasRelatedWork W2020309517 @default.
- W2885204311 hasRelatedWork W2031480185 @default.
- W2885204311 hasRelatedWork W2106937081 @default.
- W2885204311 hasRelatedWork W2107952225 @default.
- W2885204311 hasRelatedWork W2134359312 @default.
- W2885204311 hasRelatedWork W2140024026 @default.
- W2885204311 hasRelatedWork W2179211850 @default.
- W2885204311 hasRelatedWork W2267056057 @default.
- W2885204311 hasRelatedWork W2334792700 @default.
- W2885204311 hasRelatedWork W2358739719 @default.
- W2885204311 hasRelatedWork W2361291575 @default.
- W2885204311 hasRelatedWork W2487465403 @default.
- W2885204311 hasRelatedWork W2565298335 @default.
- W2885204311 hasRelatedWork W2792115510 @default.
- W2885204311 hasRelatedWork W3010235917 @default.
- W2885204311 hasRelatedWork W3011586794 @default.
- W2885204311 hasRelatedWork W3100877603 @default.
- W2885204311 hasRelatedWork W595673854 @default.
- W2885204311 hasRelatedWork W2596484811 @default.
- W2885204311 isParatext "false" @default.
- W2885204311 isRetracted "false" @default.
- W2885204311 magId "2885204311" @default.
- W2885204311 workType "article" @default.