FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885205571> ?p ?o ?g. }

• W2885205571 endingPage "4822" @default.
• W2885205571 startingPage "4805" @default.
• W2885205571 abstract "During our search for topically-active Caspase-1 inhibitors, we identified a novel class of potent inhibitors based on a 1,3,5-trisubstituted uracil motif equipped with an l-aspartate semi-aldehyde derived warhead. In the literature, the majority of Caspase-1 inhibitors possessing the same warhead have been designed and evaluated for oral administration as the ethyl acetal pro-drug form. For our topical program, the pro-drug acetal form was not fully hydrolysed in the skin and was unstable in many of our standard topical excipients, therefore, we were obliged to focus on the actual hemiacetal drug form of the molecule during our drug discovery program. Our work focuses on both the synthesis and achiral and chiral stability of the final drug molecules in topical excipients." @default.
• W2885205571 created "2018-08-22" @default.
• W2885205571 creator A5000013407 @default.
• W2885205571 creator A5002912000 @default.
• W2885205571 creator A5009956385 @default.
• W2885205571 creator A5022758717 @default.
• W2885205571 creator A5023908036 @default.
• W2885205571 creator A5027147959 @default.
• W2885205571 creator A5037655203 @default.
• W2885205571 creator A5040769083 @default.
• W2885205571 creator A5045457360 @default.
• W2885205571 creator A5052060835 @default.
• W2885205571 creator A5056481708 @default.
• W2885205571 creator A5066235492 @default.
• W2885205571 creator A5066661175 @default.
• W2885205571 creator A5068032082 @default.
• W2885205571 creator A5068841550 @default.
• W2885205571 creator A5073294663 @default.
• W2885205571 creator A5073773097 @default.
• W2885205571 creator A5076740332 @default.
• W2885205571 creator A5080799704 @default.
• W2885205571 creator A5088983479 @default.
• W2885205571 date "2018-09-01" @default.
• W2885205571 modified "2023-10-18" @default.
• W2885205571 title "Synthesis and stability evaluation of novel peptidomimetic Caspase-1 inhibitors for topical application" @default.
• W2885205571 cites W1963614127 @default.
• W2885205571 cites W1990173308 @default.
• W2885205571 cites W2014333071 @default.
• W2885205571 cites W2034933057 @default.
• W2885205571 cites W2051658957 @default.
• W2885205571 cites W2060131733 @default.
• W2885205571 cites W2071190113 @default.
• W2885205571 cites W2072397070 @default.
• W2885205571 cites W2074817486 @default.
• W2885205571 cites W2084652838 @default.
• W2885205571 cites W2085244995 @default.
• W2885205571 cites W2170226518 @default.
• W2885205571 cites W2339012377 @default.
• W2885205571 cites W2422726141 @default.
• W2885205571 cites W2555264283 @default.
• W2885205571 cites W2797302169 @default.
• W2885205571 doi "https://doi.org/10.1016/j.tet.2018.07.029" @default.
• W2885205571 hasPublicationYear "2018" @default.
• W2885205571 type Work @default.
• W2885205571 sameAs 2885205571 @default.
• W2885205571 citedByCount "1" @default.
• W2885205571 countsByYear W28852055712021 @default.
• W2885205571 crossrefType "journal-article" @default.
• W2885205571 hasAuthorship W2885205571A5000013407 @default.
• W2885205571 hasAuthorship W2885205571A5002912000 @default.
• W2885205571 hasAuthorship W2885205571A5009956385 @default.
• W2885205571 hasAuthorship W2885205571A5022758717 @default.
• W2885205571 hasAuthorship W2885205571A5023908036 @default.
• W2885205571 hasAuthorship W2885205571A5027147959 @default.
• W2885205571 hasAuthorship W2885205571A5037655203 @default.
• W2885205571 hasAuthorship W2885205571A5040769083 @default.
• W2885205571 hasAuthorship W2885205571A5045457360 @default.
• W2885205571 hasAuthorship W2885205571A5052060835 @default.
• W2885205571 hasAuthorship W2885205571A5056481708 @default.
• W2885205571 hasAuthorship W2885205571A5066235492 @default.
• W2885205571 hasAuthorship W2885205571A5066661175 @default.
• W2885205571 hasAuthorship W2885205571A5068032082 @default.
• W2885205571 hasAuthorship W2885205571A5068841550 @default.
• W2885205571 hasAuthorship W2885205571A5073294663 @default.
• W2885205571 hasAuthorship W2885205571A5073773097 @default.
• W2885205571 hasAuthorship W2885205571A5076740332 @default.
• W2885205571 hasAuthorship W2885205571A5080799704 @default.
• W2885205571 hasAuthorship W2885205571A5088983479 @default.
• W2885205571 hasBestOaLocation W28852055712 @default.
• W2885205571 hasConcept C124790011 @default.
• W2885205571 hasConcept C185592680 @default.
• W2885205571 hasConcept C21951064 @default.
• W2885205571 hasConcept C2776572972 @default.
• W2885205571 hasConcept C2777731525 @default.
• W2885205571 hasConcept C2779281246 @default.
• W2885205571 hasConcept C2780035454 @default.
• W2885205571 hasConcept C55493867 @default.
• W2885205571 hasConcept C71240020 @default.
• W2885205571 hasConcept C71924100 @default.
• W2885205571 hasConcept C98274493 @default.
• W2885205571 hasConceptScore W2885205571C124790011 @default.
• W2885205571 hasConceptScore W2885205571C185592680 @default.
• W2885205571 hasConceptScore W2885205571C21951064 @default.
• W2885205571 hasConceptScore W2885205571C2776572972 @default.
• W2885205571 hasConceptScore W2885205571C2777731525 @default.
• W2885205571 hasConceptScore W2885205571C2779281246 @default.
• W2885205571 hasConceptScore W2885205571C2780035454 @default.
• W2885205571 hasConceptScore W2885205571C55493867 @default.
• W2885205571 hasConceptScore W2885205571C71240020 @default.
• W2885205571 hasConceptScore W2885205571C71924100 @default.
• W2885205571 hasConceptScore W2885205571C98274493 @default.
• W2885205571 hasIssue "37" @default.
• W2885205571 hasLocation W28852055711 @default.
• W2885205571 hasLocation W28852055712 @default.
• W2885205571 hasLocation W28852055713 @default.
• W2885205571 hasLocation W28852055714 @default.
• W2885205571 hasLocation W28852055715 @default.
• W2885205571 hasOpenAccess W2885205571 @default.

• next