FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885206959> ?p ?o ?g. }

• W2885206959 endingPage "1303" @default.
• W2885206959 startingPage "1296" @default.
• W2885206959 abstract "Marine plants and animals have omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is required for biological processes, but humans are unable to synthesize them and must be obtained from dietary sources. EPA has been used as an antitumor agent but the molecular mechanisms for the regulation of tumor microenvironment immunity by EPA are still unknown. The indoleamine 2,3-dioxygenase 1 (IDO) catalyzes conversion of tryptophan to kynurenine to induce immune evasion in tumor microenvironment. In this study, EPA inhibited the expression of IDO via downregulation of protein kinase B (Akt)/mammalian targets of rapamycin (mTOR) signaling pathway in tumor cells. Meanwhile, a significant decrease in kynurenine levels and increase in T cell survival were observed after tumor cells treated with EPA. The results demonstrated that EPA can activate host antitumor immunity by inhibiting tumor IDO expression. Therefore, our finding suggests that EPA can be enormous potential for cancer immunotherapy." @default.
• W2885206959 created "2018-08-22" @default.
• W2885206959 creator A5017729534 @default.
• W2885206959 creator A5019745875 @default.
• W2885206959 creator A5023242114 @default.
• W2885206959 creator A5058942718 @default.
• W2885206959 creator A5066475834 @default.
• W2885206959 creator A5070963054 @default.
• W2885206959 date "2018-01-01" @default.
• W2885206959 modified "2023-10-15" @default.
• W2885206959 title "Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells" @default.
• W2885206959 cites W1562511346 @default.
• W2885206959 cites W1571546216 @default.
• W2885206959 cites W1826266252 @default.
• W2885206959 cites W1899389996 @default.
• W2885206959 cites W1980328627 @default.
• W2885206959 cites W2026429388 @default.
• W2885206959 cites W2026971086 @default.
• W2885206959 cites W2033819670 @default.
• W2885206959 cites W2038074578 @default.
• W2885206959 cites W2065019417 @default.
• W2885206959 cites W2072842707 @default.
• W2885206959 cites W2077925758 @default.
• W2885206959 cites W2086167770 @default.
• W2885206959 cites W2090410108 @default.
• W2885206959 cites W2107471253 @default.
• W2885206959 cites W2138986328 @default.
• W2885206959 cites W2146361460 @default.
• W2885206959 cites W2154436564 @default.
• W2885206959 cites W2167141436 @default.
• W2885206959 cites W2253833672 @default.
• W2885206959 cites W2275402822 @default.
• W2885206959 cites W2291779064 @default.
• W2885206959 cites W2579284243 @default.
• W2885206959 cites W2595109242 @default.
• W2885206959 cites W2615561485 @default.
• W2885206959 cites W2754519296 @default.
• W2885206959 cites W2760762766 @default.
• W2885206959 cites W2768051700 @default.
• W2885206959 cites W2775220577 @default.
• W2885206959 cites W65392852 @default.
• W2885206959 doi "https://doi.org/10.7150/ijms.27326" @default.
• W2885206959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158658" @default.
• W2885206959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275755" @default.
• W2885206959 hasPublicationYear "2018" @default.
• W2885206959 type Work @default.
• W2885206959 sameAs 2885206959 @default.
• W2885206959 citedByCount "10" @default.
• W2885206959 countsByYear W28852069592019 @default.
• W2885206959 countsByYear W28852069592020 @default.
• W2885206959 countsByYear W28852069592021 @default.
• W2885206959 countsByYear W28852069592022 @default.
• W2885206959 countsByYear W28852069592023 @default.
• W2885206959 crossrefType "journal-article" @default.
• W2885206959 hasAuthorship W2885206959A5017729534 @default.
• W2885206959 hasAuthorship W2885206959A5019745875 @default.
• W2885206959 hasAuthorship W2885206959A5023242114 @default.
• W2885206959 hasAuthorship W2885206959A5058942718 @default.
• W2885206959 hasAuthorship W2885206959A5066475834 @default.
• W2885206959 hasAuthorship W2885206959A5070963054 @default.
• W2885206959 hasBestOaLocation W28852069591 @default.
• W2885206959 hasConcept C104317684 @default.
• W2885206959 hasConcept C127561419 @default.
• W2885206959 hasConcept C185592680 @default.
• W2885206959 hasConcept C19038510 @default.
• W2885206959 hasConcept C203014093 @default.
• W2885206959 hasConcept C2776091944 @default.
• W2885206959 hasConcept C2776107976 @default.
• W2885206959 hasConcept C2776706248 @default.
• W2885206959 hasConcept C2776710720 @default.
• W2885206959 hasConcept C2777171753 @default.
• W2885206959 hasConcept C2777503454 @default.
• W2885206959 hasConcept C2777701055 @default.
• W2885206959 hasConcept C2779341262 @default.
• W2885206959 hasConcept C502942594 @default.
• W2885206959 hasConcept C515207424 @default.
• W2885206959 hasConcept C543025807 @default.
• W2885206959 hasConcept C55493867 @default.
• W2885206959 hasConcept C62478195 @default.
• W2885206959 hasConcept C75217442 @default.
• W2885206959 hasConcept C83478079 @default.
• W2885206959 hasConcept C86554907 @default.
• W2885206959 hasConcept C86803240 @default.
• W2885206959 hasConcept C8891405 @default.
• W2885206959 hasConcept C95444343 @default.
• W2885206959 hasConceptScore W2885206959C104317684 @default.
• W2885206959 hasConceptScore W2885206959C127561419 @default.
• W2885206959 hasConceptScore W2885206959C185592680 @default.
• W2885206959 hasConceptScore W2885206959C19038510 @default.
• W2885206959 hasConceptScore W2885206959C203014093 @default.
• W2885206959 hasConceptScore W2885206959C2776091944 @default.
• W2885206959 hasConceptScore W2885206959C2776107976 @default.
• W2885206959 hasConceptScore W2885206959C2776706248 @default.
• W2885206959 hasConceptScore W2885206959C2776710720 @default.
• W2885206959 hasConceptScore W2885206959C2777171753 @default.
• W2885206959 hasConceptScore W2885206959C2777503454 @default.
• W2885206959 hasConceptScore W2885206959C2777701055 @default.
• W2885206959 hasConceptScore W2885206959C2779341262 @default.

• next