FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885222356> ?p ?o ?g. }

• W2885222356 endingPage "250" @default.
• W2885222356 startingPage "238" @default.
• W2885222356 abstract "Abstract Aims/Introduction A high‐carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not a high‐carbohydrate diet affects β‐cell mass ( BCM ) has been little investigated. Materials and Methods Both wild‐type ( WT ) mice and adenosine triphosphate‐sensitive potassium channel‐deficient (Kir6.2 KO ) mice were fed normal chow or high‐starch ( ST ) diets for 22 weeks. BCM and the numbers of islets were analyzed by immunohistochemistry, and gene expression levels in islets were investigated by quantitative real‐time reverse transcription polymerase chain reaction. MIN 6‐K8 β‐cells were stimulated in solution containing various concentrations of glucose combined with nifedipine and glimepiride, and gene expression was analyzed. Results Both WT and Kir6.2 KO mice fed ST showed hyperinsulinemia and body weight gain. BCM , the number of islets and the expression levels of cyclinD2 messenger ribonucleic acid were increased in WT mice fed ST compared with those in WT mice fed normal chow. In contrast, no significant difference in BCM , the number of islets or the expression levels of cyclinD2 messenger ribonucleic acid were observed between Kir6.2 KO mice fed normal chow and those fed ST . Incubation of MIN 6‐K8 β‐cells in high‐glucose media or with glimepiride increased cyclinD2 expression, whereas nifedipine attenuated a high‐glucose‐induced increase in cyclinD2 expression. Conclusions These results show that a high‐starch diet increases BCM in an adenosine triphosphate‐sensitive potassium channel‐dependent manner, which is mediated through upregulation of cyclinD2 expression." @default.
• W2885222356 created "2018-08-22" @default.
• W2885222356 creator A5022899214 @default.
• W2885222356 creator A5041098371 @default.
• W2885222356 creator A5041204430 @default.
• W2885222356 creator A5061164859 @default.
• W2885222356 creator A5063760366 @default.
• W2885222356 creator A5065958668 @default.
• W2885222356 creator A5067006897 @default.
• W2885222356 creator A5067109592 @default.
• W2885222356 creator A5067723444 @default.
• W2885222356 creator A5072590785 @default.
• W2885222356 creator A5083059550 @default.
• W2885222356 date "2018-09-04" @default.
• W2885222356 modified "2023-10-16" @default.
• W2885222356 title "Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass" @default.
• W2885222356 cites W1526229661 @default.
• W2885222356 cites W1589501680 @default.
• W2885222356 cites W1697523131 @default.
• W2885222356 cites W1794038664 @default.
• W2885222356 cites W1964049940 @default.
• W2885222356 cites W1966143184 @default.
• W2885222356 cites W1971654760 @default.
• W2885222356 cites W1982391086 @default.
• W2885222356 cites W1995646241 @default.
• W2885222356 cites W2004466285 @default.
• W2885222356 cites W2008389112 @default.
• W2885222356 cites W2010561590 @default.
• W2885222356 cites W2011267160 @default.
• W2885222356 cites W2011747410 @default.
• W2885222356 cites W2015413597 @default.
• W2885222356 cites W2019024229 @default.
• W2885222356 cites W2026382359 @default.
• W2885222356 cites W2040692229 @default.
• W2885222356 cites W2040715474 @default.
• W2885222356 cites W2043431165 @default.
• W2885222356 cites W2047169725 @default.
• W2885222356 cites W2049033217 @default.
• W2885222356 cites W2051567027 @default.
• W2885222356 cites W2059379685 @default.
• W2885222356 cites W2064721941 @default.
• W2885222356 cites W2077484072 @default.
• W2885222356 cites W2078776299 @default.
• W2885222356 cites W2079088793 @default.
• W2885222356 cites W2082466457 @default.
• W2885222356 cites W2095765492 @default.
• W2885222356 cites W2096800210 @default.
• W2885222356 cites W2105407346 @default.
• W2885222356 cites W2105595222 @default.
• W2885222356 cites W2107635309 @default.
• W2885222356 cites W2111404063 @default.
• W2885222356 cites W2112163266 @default.
• W2885222356 cites W2118658979 @default.
• W2885222356 cites W2121274450 @default.
• W2885222356 cites W2125650289 @default.
• W2885222356 cites W2133560510 @default.
• W2885222356 cites W2134747485 @default.
• W2885222356 cites W2135093809 @default.
• W2885222356 cites W2138463340 @default.
• W2885222356 cites W2143539807 @default.
• W2885222356 cites W2146921827 @default.
• W2885222356 cites W2161542744 @default.
• W2885222356 cites W2163803503 @default.
• W2885222356 cites W2167977281 @default.
• W2885222356 cites W2171814772 @default.
• W2885222356 cites W2186209069 @default.
• W2885222356 cites W2238331813 @default.
• W2885222356 cites W2328774201 @default.
• W2885222356 cites W2579681288 @default.
• W2885222356 cites W2615234683 @default.
• W2885222356 cites W2737066966 @default.
• W2885222356 cites W2787019186 @default.
• W2885222356 cites W2885222356 @default.
• W2885222356 cites W4230231446 @default.
• W2885222356 cites W4232624821 @default.
• W2885222356 cites W4255925138 @default.
• W2885222356 doi "https://doi.org/10.1111/jdi.12907" @default.
• W2885222356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400177" @default.
• W2885222356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30084544" @default.
• W2885222356 hasPublicationYear "2018" @default.
• W2885222356 type Work @default.
• W2885222356 sameAs 2885222356 @default.
• W2885222356 citedByCount "8" @default.
• W2885222356 countsByYear W28852223562019 @default.
• W2885222356 countsByYear W28852223562020 @default.
• W2885222356 countsByYear W28852223562021 @default.
• W2885222356 countsByYear W28852223562022 @default.
• W2885222356 countsByYear W28852223562023 @default.
• W2885222356 crossrefType "journal-article" @default.
• W2885222356 hasAuthorship W2885222356A5022899214 @default.
• W2885222356 hasAuthorship W2885222356A5041098371 @default.
• W2885222356 hasAuthorship W2885222356A5041204430 @default.
• W2885222356 hasAuthorship W2885222356A5061164859 @default.
• W2885222356 hasAuthorship W2885222356A5063760366 @default.
• W2885222356 hasAuthorship W2885222356A5065958668 @default.
• W2885222356 hasAuthorship W2885222356A5067006897 @default.
• W2885222356 hasAuthorship W2885222356A5067109592 @default.
• W2885222356 hasAuthorship W2885222356A5067723444 @default.

• next