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- W2885222712 abstract "Background—Idiopathic dilated cardiomyopathy (IDC) frequently is a progressive disease without causative therapy options. Following the hypothesis that in certain patients autoantibodies against cardiac structures may induce, maintain, or promote the progression of the disease, we investigated whether the elimination of these autoantibodies through immunoadsorption would improve cardiac function. Methods and Results—This prospective case-control study included 34 patients with IDC. Each patient presented with moderate to severe heart failure and evidence of autoantibodies directed against β1-adrenoceptors (β1-AABs). Seventeen patients received standard medical therapy (control group), whereas 17 were also treated with immunoadsorption (treatment group) to eliminate β1-AABs. A 1-year follow-up included echocardiographic assessment of left ventricular ejection fraction and internal diameters, β1-AAB levels, and clinical status every 3 months. Within 1 year, the mean±SD left ventricular ejection fraction ros..." @default.
- W2885222712 created "2018-08-22" @default.
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- W2885222712 date "2000-02-01" @default.
- W2885222712 modified "2023-09-24" @default.
- W2885222712 title "Immunoglobulin Adsorption in Patients With Idiopathic Dilated Cardiomyopathy" @default.
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