Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885223507> ?p ?o ?g. }
- W2885223507 abstract "Thalassemia intermedia (TI) describes a disease ranging in severity between β thalassemia major (TM) and β thalassemia trait. Osteoporosis is observed in TI and TM. The exact reason of osteoporosis in TI could be hypogonadism and/or an increase in erythropoietin (EPO) levels. The carboxy-terminal collagen cross links (CTX), a marker of bone resorption, and the N-terminal propeptide of type 1 collagen (P1NP), a marker of bone formation are serum markers of osteoporosis. The receptor activator of NF-kappaB ligand (RANKL)/receptor activator of NF-kappaB (RANK)/osteoprotegerin (OPG) axis plays an important role in metabolic bone diseases. Herein, we tested the relationship between the RANKL/RANK/OPG axis and the bone-turnover markers CTX and P1NP in TI. We recruited 44 TI patients and 33 non-thalassemic controls and measured the serum levels of hemoglobin, sex steroid hormones, CTX, P1NP, RANKL and OPG. We then used a general linear model to test the association of the above variables with CTX and P1NP as outcome variables. We showed that EPO levels were the strongest predictor of CTX change (P < 0.000), followed by RANKL (P = 0.017). On the other hand, RANKL was the strongest predictor of P1NP change (P < 0.000), followed by OPG (P = 0.009) and EPO (P = 0.024)." @default.
- W2885223507 created "2018-08-22" @default.
- W2885223507 creator A5026117112 @default.
- W2885223507 creator A5032005595 @default.
- W2885223507 creator A5037384724 @default.
- W2885223507 creator A5046738733 @default.
- W2885223507 creator A5059896659 @default.
- W2885223507 creator A5076736502 @default.
- W2885223507 date "2018-07-31" @default.
- W2885223507 modified "2023-10-06" @default.
- W2885223507 title "Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients" @default.
- W2885223507 cites W1598874638 @default.
- W2885223507 cites W1604244149 @default.
- W2885223507 cites W1965688828 @default.
- W2885223507 cites W2005779589 @default.
- W2885223507 cites W2014225480 @default.
- W2885223507 cites W2029963804 @default.
- W2885223507 cites W2033069193 @default.
- W2885223507 cites W2045197265 @default.
- W2885223507 cites W2048250634 @default.
- W2885223507 cites W2055590859 @default.
- W2885223507 cites W2061097390 @default.
- W2885223507 cites W2072050034 @default.
- W2885223507 cites W2087193913 @default.
- W2885223507 cites W2089184786 @default.
- W2885223507 cites W2093252878 @default.
- W2885223507 cites W2094465795 @default.
- W2885223507 cites W2100946686 @default.
- W2885223507 cites W2120053954 @default.
- W2885223507 cites W2137028471 @default.
- W2885223507 cites W2138441100 @default.
- W2885223507 cites W2144196227 @default.
- W2885223507 cites W2151682604 @default.
- W2885223507 cites W2340685677 @default.
- W2885223507 cites W4300909816 @default.
- W2885223507 cites W65243549 @default.
- W2885223507 doi "https://doi.org/10.1186/s13104-018-3616-y" @default.
- W2885223507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6069879" @default.
- W2885223507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30064480" @default.
- W2885223507 hasPublicationYear "2018" @default.
- W2885223507 type Work @default.
- W2885223507 sameAs 2885223507 @default.
- W2885223507 citedByCount "7" @default.
- W2885223507 countsByYear W28852235072019 @default.
- W2885223507 countsByYear W28852235072021 @default.
- W2885223507 countsByYear W28852235072022 @default.
- W2885223507 crossrefType "journal-article" @default.
- W2885223507 hasAuthorship W2885223507A5026117112 @default.
- W2885223507 hasAuthorship W2885223507A5032005595 @default.
- W2885223507 hasAuthorship W2885223507A5037384724 @default.
- W2885223507 hasAuthorship W2885223507A5046738733 @default.
- W2885223507 hasAuthorship W2885223507A5059896659 @default.
- W2885223507 hasAuthorship W2885223507A5076736502 @default.
- W2885223507 hasBestOaLocation W28852235071 @default.
- W2885223507 hasConcept C126322002 @default.
- W2885223507 hasConcept C134018914 @default.
- W2885223507 hasConcept C170033053 @default.
- W2885223507 hasConcept C170493617 @default.
- W2885223507 hasConcept C2776541429 @default.
- W2885223507 hasConcept C2777799968 @default.
- W2885223507 hasConcept C2779240191 @default.
- W2885223507 hasConcept C2779428903 @default.
- W2885223507 hasConcept C2780426850 @default.
- W2885223507 hasConcept C673006 @default.
- W2885223507 hasConcept C71924100 @default.
- W2885223507 hasConcept C88045685 @default.
- W2885223507 hasConceptScore W2885223507C126322002 @default.
- W2885223507 hasConceptScore W2885223507C134018914 @default.
- W2885223507 hasConceptScore W2885223507C170033053 @default.
- W2885223507 hasConceptScore W2885223507C170493617 @default.
- W2885223507 hasConceptScore W2885223507C2776541429 @default.
- W2885223507 hasConceptScore W2885223507C2777799968 @default.
- W2885223507 hasConceptScore W2885223507C2779240191 @default.
- W2885223507 hasConceptScore W2885223507C2779428903 @default.
- W2885223507 hasConceptScore W2885223507C2780426850 @default.
- W2885223507 hasConceptScore W2885223507C673006 @default.
- W2885223507 hasConceptScore W2885223507C71924100 @default.
- W2885223507 hasConceptScore W2885223507C88045685 @default.
- W2885223507 hasIssue "1" @default.
- W2885223507 hasLocation W28852235071 @default.
- W2885223507 hasLocation W28852235072 @default.
- W2885223507 hasLocation W28852235073 @default.
- W2885223507 hasLocation W28852235074 @default.
- W2885223507 hasLocation W28852235075 @default.
- W2885223507 hasOpenAccess W2885223507 @default.
- W2885223507 hasPrimaryLocation W28852235071 @default.
- W2885223507 hasRelatedWork W1975953388 @default.
- W2885223507 hasRelatedWork W2016178145 @default.
- W2885223507 hasRelatedWork W2026854426 @default.
- W2885223507 hasRelatedWork W2076556813 @default.
- W2885223507 hasRelatedWork W2088025468 @default.
- W2885223507 hasRelatedWork W2124998345 @default.
- W2885223507 hasRelatedWork W2326832210 @default.
- W2885223507 hasRelatedWork W2359067194 @default.
- W2885223507 hasRelatedWork W2360822669 @default.
- W2885223507 hasRelatedWork W2377888814 @default.
- W2885223507 hasVolume "11" @default.
- W2885223507 isParatext "false" @default.
- W2885223507 isRetracted "false" @default.
- W2885223507 magId "2885223507" @default.