Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885227302> ?p ?o ?g. }
- W2885227302 endingPage "814" @default.
- W2885227302 startingPage "799" @default.
- W2885227302 abstract "The mechanism of neurodegeneration in Parkinson’s disease (PD) remains unknown but it has been hypothesised that the intestinal tract could be an initiating and contributing factor to the neurodegenerative processes. In PD patients as well as in animal models for PD, alpha-synuclein-positive enteric neurons in the colon and evidence of colonic inflammation have been demonstrated. Moreover, several studies reported pro-inflammatory bacterial dysbiosis in PD patients. Here, we report for the first time significant changes in the composition of caecum mucosal associated and luminal microbiota and the associated metabolic pathways in a rotenone-induced mouse model for PD. The mouse model for PD, induced by the pesticide rotenone, is associated with an imbalance in the gut microbiota, characterised by a significant decrease in the relative abundance of the beneficial commensal bacteria genus Bifidobacterium. Overall, intestinal bacterial dysbiosis might play an important role in both the disruption of intestinal epithelial integrity and intestinal inflammation, which could lead or contribute to the observed alpha-synuclein aggregation and PD pathology in the intestine and central nervous system in the oral rotenone mouse model of PD." @default.
- W2885227302 created "2018-08-22" @default.
- W2885227302 creator A5002619544 @default.
- W2885227302 creator A5021596527 @default.
- W2885227302 creator A5023267835 @default.
- W2885227302 creator A5036619125 @default.
- W2885227302 creator A5049533183 @default.
- W2885227302 creator A5051663918 @default.
- W2885227302 creator A5052916600 @default.
- W2885227302 creator A5062131424 @default.
- W2885227302 creator A5088776895 @default.
- W2885227302 date "2018-09-18" @default.
- W2885227302 modified "2023-10-18" @default.
- W2885227302 title "Gut bacterial composition in a mouse model of Parkinson’s disease" @default.
- W2885227302 cites W1515023627 @default.
- W2885227302 cites W1566264161 @default.
- W2885227302 cites W1621325175 @default.
- W2885227302 cites W1716352502 @default.
- W2885227302 cites W1779994739 @default.
- W2885227302 cites W1947901277 @default.
- W2885227302 cites W1965942744 @default.
- W2885227302 cites W1971775466 @default.
- W2885227302 cites W1977267085 @default.
- W2885227302 cites W1981500982 @default.
- W2885227302 cites W1983564695 @default.
- W2885227302 cites W1992780204 @default.
- W2885227302 cites W1995281235 @default.
- W2885227302 cites W1998767819 @default.
- W2885227302 cites W1999722943 @default.
- W2885227302 cites W2011030038 @default.
- W2885227302 cites W2015908777 @default.
- W2885227302 cites W2016704608 @default.
- W2885227302 cites W2026544197 @default.
- W2885227302 cites W2028944525 @default.
- W2885227302 cites W2034151625 @default.
- W2885227302 cites W2046189898 @default.
- W2885227302 cites W2050920580 @default.
- W2885227302 cites W2051517155 @default.
- W2885227302 cites W2067530525 @default.
- W2885227302 cites W2072970694 @default.
- W2885227302 cites W2078378773 @default.
- W2885227302 cites W2087519383 @default.
- W2885227302 cites W2087812097 @default.
- W2885227302 cites W2088662726 @default.
- W2885227302 cites W2092001531 @default.
- W2885227302 cites W2092894985 @default.
- W2885227302 cites W2097335121 @default.
- W2885227302 cites W2098762803 @default.
- W2885227302 cites W2104251890 @default.
- W2885227302 cites W2104419318 @default.
- W2885227302 cites W2108281900 @default.
- W2885227302 cites W2110300022 @default.
- W2885227302 cites W2120501335 @default.
- W2885227302 cites W2124351063 @default.
- W2885227302 cites W2130731460 @default.
- W2885227302 cites W2134068760 @default.
- W2885227302 cites W2136759951 @default.
- W2885227302 cites W2139190685 @default.
- W2885227302 cites W2145158133 @default.
- W2885227302 cites W2148103005 @default.
- W2885227302 cites W2149522871 @default.
- W2885227302 cites W2156411508 @default.
- W2885227302 cites W2160937374 @default.
- W2885227302 cites W2162965492 @default.
- W2885227302 cites W2163878401 @default.
- W2885227302 cites W2165976376 @default.
- W2885227302 cites W2166171121 @default.
- W2885227302 cites W2171742795 @default.
- W2885227302 cites W2200372542 @default.
- W2885227302 cites W2277411172 @default.
- W2885227302 cites W2293877091 @default.
- W2885227302 cites W2309910088 @default.
- W2885227302 cites W2332863458 @default.
- W2885227302 cites W2340717842 @default.
- W2885227302 cites W2508023300 @default.
- W2885227302 cites W2517534055 @default.
- W2885227302 cites W2558041282 @default.
- W2885227302 cites W2573367782 @default.
- W2885227302 cites W2582882943 @default.
- W2885227302 cites W2589302738 @default.
- W2885227302 cites W2607019262 @default.
- W2885227302 cites W2608965099 @default.
- W2885227302 cites W2609340709 @default.
- W2885227302 cites W2613763302 @default.
- W2885227302 cites W2616539606 @default.
- W2885227302 cites W2766355490 @default.
- W2885227302 cites W2782323684 @default.
- W2885227302 cites W2789725922 @default.
- W2885227302 cites W2946614008 @default.
- W2885227302 cites W4211032576 @default.
- W2885227302 cites W4294216483 @default.
- W2885227302 doi "https://doi.org/10.3920/bm2017.0202" @default.
- W2885227302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30099890" @default.
- W2885227302 hasPublicationYear "2018" @default.
- W2885227302 type Work @default.
- W2885227302 sameAs 2885227302 @default.
- W2885227302 citedByCount "67" @default.
- W2885227302 countsByYear W28852273022018 @default.