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- W2885229294 abstract "Abstract Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as a microRNA sponge, RNA binding protein sponge and translational regulator. CircRNAs have become a research hotspot because of their close association with the development of diseases. Some circRNAs are reportedly expressed in a tissue- and development stage-specific manner. Furthermore, due to other features of circRNAs including stability, conservation and high abundance in body fluids, circRNAs are believed to be potential biomarkers for various diseases. In the present review, we provide the current understanding of biogenesis and gene regulatory mechanisms of circRNAs, summarize the recent studies on circRNAs as potential diagnostic and prognostic biomarkers, and highlight the major advantages and limitations of circRNAs as novel biomarkers based on existing knowledge." @default.
- W2885229294 created "2018-08-22" @default.
- W2885229294 creator A5012318743 @default.
- W2885229294 creator A5065745300 @default.
- W2885229294 creator A5069351194 @default.
- W2885229294 date "2018-08-01" @default.
- W2885229294 modified "2023-10-17" @default.
- W2885229294 title "Circular RNAs: Promising Biomarkers for Human Diseases" @default.
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- W2885229294 doi "https://doi.org/10.1016/j.ebiom.2018.07.036" @default.
- W2885229294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6116471" @default.
- W2885229294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30078734" @default.
- W2885229294 hasPublicationYear "2018" @default.
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