FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885242248> ?p ?o ?g. }

• W2885242248 endingPage "1710" @default.
• W2885242248 startingPage "1703" @default.
• W2885242248 abstract "We previously reported a profound augmentation in the hepatic levels of a pro-inflammatory precursor, arachidonic acid (AA), during liver tumorigenesis. Here, we report a critical role of the induced reactive oxygen species (ROS)-mediated cellular activation of a protein cross-linking enzyme, transglutaminase 2 (TG2), in liver injury by AA. In cultures of hepatic cells, AA dose-dependently suppressed cell growth, which accompanied the induced nuclear accumulation of TG2, as demonstrated in EGFP-tagged, TG2-overexpressing hepatic cells. A chemical inhibitor/shRNA that acts against TG2 prevented AA-mediated cell growth suppression. In addition, AA provoked significant production of ROS, and antioxidants blocked AA-induced activation of nuclear TG2 and hepatic cell growth suppression. We propose that AA-mediated oxidative stress and TG2 transamidase activity might contribute to chronic liver injury and inflammation and thereby serve as potential therapeutic targets for the chemoprevention of hepatocellular carcinoma." @default.
• W2885242248 created "2018-08-22" @default.
• W2885242248 creator A5002127115 @default.
• W2885242248 creator A5002139080 @default.
• W2885242248 creator A5005061456 @default.
• W2885242248 date "2018-09-11" @default.
• W2885242248 modified "2023-10-16" @default.
• W2885242248 title "Arachidonic acid suppresses hepatic cell growth through <scp>ROS</scp> ‐mediated activation of transglutaminase" @default.
• W2885242248 cites W175518023 @default.
• W2885242248 cites W1888592485 @default.
• W2885242248 cites W1972008715 @default.
• W2885242248 cites W2007359989 @default.
• W2885242248 cites W2029913181 @default.
• W2885242248 cites W2031626820 @default.
• W2885242248 cites W2037705731 @default.
• W2885242248 cites W2053047691 @default.
• W2885242248 cites W2074648434 @default.
• W2885242248 cites W2101443017 @default.
• W2885242248 cites W2131236880 @default.
• W2885242248 cites W2148784782 @default.
• W2885242248 cites W2222528065 @default.
• W2885242248 cites W2289068089 @default.
• W2885242248 cites W2411985919 @default.
• W2885242248 cites W2416163312 @default.
• W2885242248 cites W2523585587 @default.
• W2885242248 cites W2729753755 @default.
• W2885242248 cites W2754771940 @default.
• W2885242248 cites W2801937548 @default.
• W2885242248 doi "https://doi.org/10.1002/2211-5463.12511" @default.
• W2885242248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168684" @default.
• W2885242248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30338220" @default.
• W2885242248 hasPublicationYear "2018" @default.
• W2885242248 type Work @default.
• W2885242248 sameAs 2885242248 @default.
• W2885242248 citedByCount "8" @default.
• W2885242248 countsByYear W28852422482019 @default.
• W2885242248 countsByYear W28852422482020 @default.
• W2885242248 countsByYear W28852422482021 @default.
• W2885242248 countsByYear W28852422482022 @default.
• W2885242248 countsByYear W28852422482023 @default.
• W2885242248 crossrefType "journal-article" @default.
• W2885242248 hasAuthorship W2885242248A5002127115 @default.
• W2885242248 hasAuthorship W2885242248A5002139080 @default.
• W2885242248 hasAuthorship W2885242248A5005061456 @default.
• W2885242248 hasBestOaLocation W28852422481 @default.
• W2885242248 hasConcept C104317684 @default.
• W2885242248 hasConcept C1491633281 @default.
• W2885242248 hasConcept C173396325 @default.
• W2885242248 hasConcept C178498320 @default.
• W2885242248 hasConcept C181199279 @default.
• W2885242248 hasConcept C185592680 @default.
• W2885242248 hasConcept C190232843 @default.
• W2885242248 hasConcept C190283241 @default.
• W2885242248 hasConcept C203014093 @default.
• W2885242248 hasConcept C2776151105 @default.
• W2885242248 hasConcept C2776914184 @default.
• W2885242248 hasConcept C2778078955 @default.
• W2885242248 hasConcept C48349386 @default.
• W2885242248 hasConcept C502942594 @default.
• W2885242248 hasConcept C55493867 @default.
• W2885242248 hasConcept C555283112 @default.
• W2885242248 hasConcept C62112901 @default.
• W2885242248 hasConcept C86803240 @default.
• W2885242248 hasConcept C95444343 @default.
• W2885242248 hasConceptScore W2885242248C104317684 @default.
• W2885242248 hasConceptScore W2885242248C1491633281 @default.
• W2885242248 hasConceptScore W2885242248C173396325 @default.
• W2885242248 hasConceptScore W2885242248C178498320 @default.
• W2885242248 hasConceptScore W2885242248C181199279 @default.
• W2885242248 hasConceptScore W2885242248C185592680 @default.
• W2885242248 hasConceptScore W2885242248C190232843 @default.
• W2885242248 hasConceptScore W2885242248C190283241 @default.
• W2885242248 hasConceptScore W2885242248C203014093 @default.
• W2885242248 hasConceptScore W2885242248C2776151105 @default.
• W2885242248 hasConceptScore W2885242248C2776914184 @default.
• W2885242248 hasConceptScore W2885242248C2778078955 @default.
• W2885242248 hasConceptScore W2885242248C48349386 @default.
• W2885242248 hasConceptScore W2885242248C502942594 @default.
• W2885242248 hasConceptScore W2885242248C55493867 @default.
• W2885242248 hasConceptScore W2885242248C555283112 @default.
• W2885242248 hasConceptScore W2885242248C62112901 @default.
• W2885242248 hasConceptScore W2885242248C86803240 @default.
• W2885242248 hasConceptScore W2885242248C95444343 @default.
• W2885242248 hasFunder F4320320912 @default.
• W2885242248 hasFunder F4320321001 @default.
• W2885242248 hasIssue "10" @default.
• W2885242248 hasLocation W28852422481 @default.
• W2885242248 hasLocation W28852422482 @default.
• W2885242248 hasLocation W28852422483 @default.
• W2885242248 hasLocation W28852422484 @default.
• W2885242248 hasLocation W28852422485 @default.
• W2885242248 hasOpenAccess W2885242248 @default.
• W2885242248 hasPrimaryLocation W28852422481 @default.
• W2885242248 hasRelatedWork W143687651 @default.
• W2885242248 hasRelatedWork W1967423388 @default.
• W2885242248 hasRelatedWork W2044156224 @default.
• W2885242248 hasRelatedWork W2102856042 @default.
• W2885242248 hasRelatedWork W2318381739 @default.

• next