Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885245587> ?p ?o ?g. }
- W2885245587 endingPage "528" @default.
- W2885245587 startingPage "521" @default.
- W2885245587 abstract "In patients with primary sclerosing cholangitis (PSC), ursodeoxycholic acid (UDCA) treatment improves serum liver tests and surrogate markers of prognosis but has no proven effect on survival. Additional therapies are obviously needed. Fibrates, PPAR agonists with anti-cholestatic properties, have a beneficial effect in primary biliary cholangitis. The aim of this study was to evaluate the safety and efficacy of fibrates in PSC patients. Retrospectively, we investigated PSC patients treated with fibrates (fenofibrate 200 mg/day or bezafibrate 400 mg/day) for at least 6 months in addition to UDCA, after an incomplete biochemical response (alkaline phosphatase [ALP] ≥ 1.5 × upper limit of normal) to UDCA. Changes in biochemical parameters and clinical features were assessed. Twenty patients were included (fourteen from Paris and six from Barcelona): median age 43.8 years, median liver stiffness 11 kPa (≥ F3). Upon treatment with fibrates (median duration of 1.56 years), liver tests significantly improved, including a reduction of ALP levels by 41% and pruritus significantly decreased. No serious adverse event attributable to fibrates occurred. Discontinuation of fibrates was followed by a clear rebound of ALP. Despite biochemical improvement, liver stiffness significantly increased. Combining UDCA with fibrates results in a significant biochemical improvement and pruritus decrease in PSC patients with incomplete response to UDCA. These results provide a rationale for larger and prospectively designed studies to establish the efficacy and safety of fibrates in PSC." @default.
- W2885245587 created "2018-08-22" @default.
- W2885245587 creator A5032256382 @default.
- W2885245587 creator A5043299615 @default.
- W2885245587 creator A5053434760 @default.
- W2885245587 creator A5077240254 @default.
- W2885245587 creator A5078422289 @default.
- W2885245587 creator A5079187691 @default.
- W2885245587 creator A5085876744 @default.
- W2885245587 creator A5088081866 @default.
- W2885245587 creator A5088745824 @default.
- W2885245587 creator A5090413862 @default.
- W2885245587 date "2018-12-01" @default.
- W2885245587 modified "2023-10-17" @default.
- W2885245587 title "Primary sclerosing cholangitis response to the combination of fibrates with ursodeoxycholic acid: French–Spanish experience" @default.
- W2885245587 cites W1559882044 @default.
- W2885245587 cites W1726014254 @default.
- W2885245587 cites W1985970899 @default.
- W2885245587 cites W1990027295 @default.
- W2885245587 cites W1995896853 @default.
- W2885245587 cites W2019796203 @default.
- W2885245587 cites W2023000637 @default.
- W2885245587 cites W2053194502 @default.
- W2885245587 cites W2076982518 @default.
- W2885245587 cites W2079345345 @default.
- W2885245587 cites W2086602774 @default.
- W2885245587 cites W2102005215 @default.
- W2885245587 cites W2118181901 @default.
- W2885245587 cites W2129613439 @default.
- W2885245587 cites W2132474120 @default.
- W2885245587 cites W2133403920 @default.
- W2885245587 cites W2143030437 @default.
- W2885245587 cites W2146286872 @default.
- W2885245587 cites W2289861039 @default.
- W2885245587 cites W2554726321 @default.
- W2885245587 cites W2616282068 @default.
- W2885245587 cites W2762689973 @default.
- W2885245587 cites W2786456523 @default.
- W2885245587 cites W2790255143 @default.
- W2885245587 cites W2807617765 @default.
- W2885245587 cites W4233893512 @default.
- W2885245587 cites W2177198559 @default.
- W2885245587 doi "https://doi.org/10.1016/j.clinre.2018.06.009" @default.
- W2885245587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30100231" @default.
- W2885245587 hasPublicationYear "2018" @default.
- W2885245587 type Work @default.
- W2885245587 sameAs 2885245587 @default.
- W2885245587 citedByCount "37" @default.
- W2885245587 countsByYear W28852455872019 @default.
- W2885245587 countsByYear W28852455872020 @default.
- W2885245587 countsByYear W28852455872021 @default.
- W2885245587 countsByYear W28852455872022 @default.
- W2885245587 countsByYear W28852455872023 @default.
- W2885245587 crossrefType "journal-article" @default.
- W2885245587 hasAuthorship W2885245587A5032256382 @default.
- W2885245587 hasAuthorship W2885245587A5043299615 @default.
- W2885245587 hasAuthorship W2885245587A5053434760 @default.
- W2885245587 hasAuthorship W2885245587A5077240254 @default.
- W2885245587 hasAuthorship W2885245587A5078422289 @default.
- W2885245587 hasAuthorship W2885245587A5079187691 @default.
- W2885245587 hasAuthorship W2885245587A5085876744 @default.
- W2885245587 hasAuthorship W2885245587A5088081866 @default.
- W2885245587 hasAuthorship W2885245587A5088745824 @default.
- W2885245587 hasAuthorship W2885245587A5090413862 @default.
- W2885245587 hasBestOaLocation W28852455872 @default.
- W2885245587 hasConcept C126322002 @default.
- W2885245587 hasConcept C197934379 @default.
- W2885245587 hasConcept C2776362216 @default.
- W2885245587 hasConcept C2778110834 @default.
- W2885245587 hasConcept C2778715236 @default.
- W2885245587 hasConcept C2779134260 @default.
- W2885245587 hasConcept C2780567839 @default.
- W2885245587 hasConcept C2780615123 @default.
- W2885245587 hasConcept C2780965833 @default.
- W2885245587 hasConcept C71924100 @default.
- W2885245587 hasConcept C90924648 @default.
- W2885245587 hasConceptScore W2885245587C126322002 @default.
- W2885245587 hasConceptScore W2885245587C197934379 @default.
- W2885245587 hasConceptScore W2885245587C2776362216 @default.
- W2885245587 hasConceptScore W2885245587C2778110834 @default.
- W2885245587 hasConceptScore W2885245587C2778715236 @default.
- W2885245587 hasConceptScore W2885245587C2779134260 @default.
- W2885245587 hasConceptScore W2885245587C2780567839 @default.
- W2885245587 hasConceptScore W2885245587C2780615123 @default.
- W2885245587 hasConceptScore W2885245587C2780965833 @default.
- W2885245587 hasConceptScore W2885245587C71924100 @default.
- W2885245587 hasConceptScore W2885245587C90924648 @default.
- W2885245587 hasIssue "6" @default.
- W2885245587 hasLocation W28852455871 @default.
- W2885245587 hasLocation W28852455872 @default.
- W2885245587 hasLocation W28852455873 @default.
- W2885245587 hasLocation W28852455874 @default.
- W2885245587 hasOpenAccess W2885245587 @default.
- W2885245587 hasPrimaryLocation W28852455871 @default.
- W2885245587 hasRelatedWork W1590614915 @default.
- W2885245587 hasRelatedWork W2069312399 @default.
- W2885245587 hasRelatedWork W2200858106 @default.
- W2885245587 hasRelatedWork W2440868301 @default.