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• W2885247948 endingPage "2281" @default.
• W2885247948 startingPage "2281" @default.
• W2885247948 abstract "Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: −0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: −0.93 ng/mL, 95% CI: −3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: −0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions." @default.
• W2885247948 created "2018-08-22" @default.
• W2885247948 creator A5001770956 @default.
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• W2885247948 date "2018-08-03" @default.
• W2885247948 modified "2023-10-18" @default.
• W2885247948 title "Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis" @default.
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• W2885247948 doi "https://doi.org/10.3390/ijms19082281" @default.
• W2885247948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6121551" @default.
• W2885247948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30081509" @default.
• W2885247948 hasPublicationYear "2018" @default.
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