Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885248918> ?p ?o ?g. }
- W2885248918 endingPage "217" @default.
- W2885248918 startingPage "206" @default.
- W2885248918 abstract "Humans live for decades, whereas mice live for months. Over these long timescales, naïve T cells die or divide infrequently enough that it makes sense to approximate death and division as instantaneous events. The population of T cells in the body is naturally divided into clonotypes; a clonotype is the set of cells that have identical T-cell receptors. While total numbers of cells, such as naïve CD4+ T cells, are large enough that ordinary differential equations are an appropriate starting point for mathematical models, the numbers of cells per clonotype are not. Here, we review a number of basic mathematical models of the maintenance of clonal diversity. As well as deterministic models, we discuss stochastic models that explicitly track the integer number of naïve T cells in many competing clonotypes over the lifetime of a mouse or human, including the effect of waning thymic production. Experimental evaluation of clonal diversity by bulk high-throughput sequencing has many difficulties, but the use of single-cell sequencing is restricted to numbers of cells many orders of magnitude smaller than the total number of T cells in the body. Mathematical questions associated with extrapolating from small samples are therefore key to advances in understanding the diversity of the repertoire of T cells. We conclude with some mathematical models on how to advance in this area." @default.
- W2885248918 created "2018-08-22" @default.
- W2885248918 creator A5022689831 @default.
- W2885248918 creator A5053760589 @default.
- W2885248918 date "2018-08-11" @default.
- W2885248918 modified "2023-10-18" @default.
- W2885248918 title "Some deterministic and stochastic mathematical models of naïve T-cell homeostasis" @default.
- W2885248918 cites W1508696496 @default.
- W2885248918 cites W1515865309 @default.
- W2885248918 cites W1536222681 @default.
- W2885248918 cites W1595915388 @default.
- W2885248918 cites W1893260165 @default.
- W2885248918 cites W1924726281 @default.
- W2885248918 cites W1970635924 @default.
- W2885248918 cites W1971931476 @default.
- W2885248918 cites W1973639800 @default.
- W2885248918 cites W1978574683 @default.
- W2885248918 cites W1979068809 @default.
- W2885248918 cites W1984109590 @default.
- W2885248918 cites W1986216579 @default.
- W2885248918 cites W1992031335 @default.
- W2885248918 cites W1997383526 @default.
- W2885248918 cites W2000483236 @default.
- W2885248918 cites W2003717645 @default.
- W2885248918 cites W2007221590 @default.
- W2885248918 cites W2008527905 @default.
- W2885248918 cites W2010234200 @default.
- W2885248918 cites W2015310734 @default.
- W2885248918 cites W2016898005 @default.
- W2885248918 cites W2017037510 @default.
- W2885248918 cites W2018330851 @default.
- W2885248918 cites W2023550692 @default.
- W2885248918 cites W2024129676 @default.
- W2885248918 cites W2025465431 @default.
- W2885248918 cites W2037127793 @default.
- W2885248918 cites W2037566060 @default.
- W2885248918 cites W2037782555 @default.
- W2885248918 cites W2039045791 @default.
- W2885248918 cites W2043071551 @default.
- W2885248918 cites W2044560758 @default.
- W2885248918 cites W2047366270 @default.
- W2885248918 cites W2047857561 @default.
- W2885248918 cites W2049204549 @default.
- W2885248918 cites W2051939070 @default.
- W2885248918 cites W2052998574 @default.
- W2885248918 cites W2053654593 @default.
- W2885248918 cites W2064593553 @default.
- W2885248918 cites W2069043306 @default.
- W2885248918 cites W2069109607 @default.
- W2885248918 cites W2073848442 @default.
- W2885248918 cites W2080737275 @default.
- W2885248918 cites W2082595913 @default.
- W2885248918 cites W2083717367 @default.
- W2885248918 cites W2084524844 @default.
- W2885248918 cites W2086221877 @default.
- W2885248918 cites W2088597221 @default.
- W2885248918 cites W2089543767 @default.
- W2885248918 cites W2092876927 @default.
- W2885248918 cites W2098504116 @default.
- W2885248918 cites W2099088219 @default.
- W2885248918 cites W2103015997 @default.
- W2885248918 cites W2104316302 @default.
- W2885248918 cites W2105527855 @default.
- W2885248918 cites W2105600950 @default.
- W2885248918 cites W2107912726 @default.
- W2885248918 cites W2110394694 @default.
- W2885248918 cites W2110459643 @default.
- W2885248918 cites W2118342395 @default.
- W2885248918 cites W2119789840 @default.
- W2885248918 cites W2121555036 @default.
- W2885248918 cites W2135907926 @default.
- W2885248918 cites W2137086195 @default.
- W2885248918 cites W2137768533 @default.
- W2885248918 cites W2138203093 @default.
- W2885248918 cites W2140323624 @default.
- W2885248918 cites W2141312574 @default.
- W2885248918 cites W2144439874 @default.
- W2885248918 cites W2144890743 @default.
- W2885248918 cites W2149488526 @default.
- W2885248918 cites W2152407002 @default.
- W2885248918 cites W2158450091 @default.
- W2885248918 cites W2160841060 @default.
- W2885248918 cites W2161195685 @default.
- W2885248918 cites W2167670122 @default.
- W2885248918 cites W2168039974 @default.
- W2885248918 cites W2171844613 @default.
- W2885248918 cites W2173617309 @default.
- W2885248918 cites W2177466866 @default.
- W2885248918 cites W2182117355 @default.
- W2885248918 cites W2218699516 @default.
- W2885248918 cites W2224087185 @default.
- W2885248918 cites W2261563054 @default.
- W2885248918 cites W2295703274 @default.
- W2885248918 cites W2317145780 @default.
- W2885248918 cites W2337334490 @default.
- W2885248918 cites W2338977631 @default.
- W2885248918 cites W2591308900 @default.
- W2885248918 cites W2594102594 @default.