Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885251566> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2885251566 abstract "Background and Objectives: It is well known that extracellular adenosine regulates angiogenesis. However, it is unclear whether intracellular adenosine is able to modulate endothelial angiogenesis. This study is to investigate the effect of elevated intracellular adenosine caused by adenosine kinase (ADK) deletion or knockdown on endothelial angiogenesis and further to determine the involvement of adenosine receptors and methylation pathways in this effect. Methods and results: Human Umbilical Vein Endothelial Cells (HUVECs) were transfected with adenoviral ADK shRNA. ADK knockdown elevated the level of intracellular adenosine, and consequently increased endothelial migration and proliferation. The latter was accompanied with an increase in VEGFR2 expression and PI3K-Akt activation and a decrease of global DNA methylation. Treatment of HUVEC with S-adenosylmethionine or DNA transmethylase inhibitor 5-aza-2-deoxycytodine abolished ADK-knockdown induced VEGFR2 expression and angiogenesis. VEGFR2 expression ..." @default.
- W2885251566 created "2018-08-22" @default.
- W2885251566 creator A5004268401 @default.
- W2885251566 creator A5011689459 @default.
- W2885251566 creator A5012978458 @default.
- W2885251566 creator A5013977142 @default.
- W2885251566 creator A5048957507 @default.
- W2885251566 creator A5054393377 @default.
- W2885251566 creator A5064982515 @default.
- W2885251566 date "2015-05-01" @default.
- W2885251566 modified "2023-09-23" @default.
- W2885251566 title "Abstract 10: Endothelial Intracellular Adenosine Epigenetically Regulates Angiogenesis" @default.
- W2885251566 hasPublicationYear "2015" @default.
- W2885251566 type Work @default.
- W2885251566 sameAs 2885251566 @default.
- W2885251566 citedByCount "0" @default.
- W2885251566 crossrefType "journal-article" @default.
- W2885251566 hasAuthorship W2885251566A5004268401 @default.
- W2885251566 hasAuthorship W2885251566A5011689459 @default.
- W2885251566 hasAuthorship W2885251566A5012978458 @default.
- W2885251566 hasAuthorship W2885251566A5013977142 @default.
- W2885251566 hasAuthorship W2885251566A5048957507 @default.
- W2885251566 hasAuthorship W2885251566A5054393377 @default.
- W2885251566 hasAuthorship W2885251566A5064982515 @default.
- W2885251566 hasConcept C104317684 @default.
- W2885251566 hasConcept C173396325 @default.
- W2885251566 hasConcept C185592680 @default.
- W2885251566 hasConcept C190283241 @default.
- W2885251566 hasConcept C202751555 @default.
- W2885251566 hasConcept C2776991684 @default.
- W2885251566 hasConcept C2777411675 @default.
- W2885251566 hasConcept C2780394083 @default.
- W2885251566 hasConcept C2780876210 @default.
- W2885251566 hasConcept C34628245 @default.
- W2885251566 hasConcept C502942594 @default.
- W2885251566 hasConcept C54009773 @default.
- W2885251566 hasConcept C55493867 @default.
- W2885251566 hasConcept C79879829 @default.
- W2885251566 hasConcept C86803240 @default.
- W2885251566 hasConcept C95444343 @default.
- W2885251566 hasConceptScore W2885251566C104317684 @default.
- W2885251566 hasConceptScore W2885251566C173396325 @default.
- W2885251566 hasConceptScore W2885251566C185592680 @default.
- W2885251566 hasConceptScore W2885251566C190283241 @default.
- W2885251566 hasConceptScore W2885251566C202751555 @default.
- W2885251566 hasConceptScore W2885251566C2776991684 @default.
- W2885251566 hasConceptScore W2885251566C2777411675 @default.
- W2885251566 hasConceptScore W2885251566C2780394083 @default.
- W2885251566 hasConceptScore W2885251566C2780876210 @default.
- W2885251566 hasConceptScore W2885251566C34628245 @default.
- W2885251566 hasConceptScore W2885251566C502942594 @default.
- W2885251566 hasConceptScore W2885251566C54009773 @default.
- W2885251566 hasConceptScore W2885251566C55493867 @default.
- W2885251566 hasConceptScore W2885251566C79879829 @default.
- W2885251566 hasConceptScore W2885251566C86803240 @default.
- W2885251566 hasConceptScore W2885251566C95444343 @default.
- W2885251566 hasLocation W28852515661 @default.
- W2885251566 hasOpenAccess W2885251566 @default.
- W2885251566 hasPrimaryLocation W28852515661 @default.
- W2885251566 hasRelatedWork W1135850556 @default.
- W2885251566 hasRelatedWork W1967426336 @default.
- W2885251566 hasRelatedWork W1989453119 @default.
- W2885251566 hasRelatedWork W2000584704 @default.
- W2885251566 hasRelatedWork W2025422383 @default.
- W2885251566 hasRelatedWork W2067027806 @default.
- W2885251566 hasRelatedWork W2088070680 @default.
- W2885251566 hasRelatedWork W2092118563 @default.
- W2885251566 hasRelatedWork W2108525961 @default.
- W2885251566 hasRelatedWork W2112725004 @default.
- W2885251566 hasRelatedWork W2125353422 @default.
- W2885251566 hasRelatedWork W2138168819 @default.
- W2885251566 hasRelatedWork W2169876742 @default.
- W2885251566 hasRelatedWork W2293749951 @default.
- W2885251566 hasRelatedWork W2515536469 @default.
- W2885251566 hasRelatedWork W2737693282 @default.
- W2885251566 hasRelatedWork W2782651279 @default.
- W2885251566 hasRelatedWork W2810532541 @default.
- W2885251566 hasRelatedWork W3194167618 @default.
- W2885251566 hasRelatedWork W25780979 @default.
- W2885251566 isParatext "false" @default.
- W2885251566 isRetracted "false" @default.
- W2885251566 magId "2885251566" @default.
- W2885251566 workType "article" @default.