FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885266232> ?p ?o ?g. }

• W2885266232 endingPage "278" @default.
• W2885266232 startingPage "267" @default.
• W2885266232 abstract "C-type lectins (CTLs) have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. Asialoglycoprotein receptor (ASGPR), also known as hepatic lectin, a member of CTLs, was the first animal lectin identified, yet information regarding it remains rather limited in teleost. In this study, we identified a putative protein in zebrafish, named as the zebrafish hepatic lectin (Zhl). The zhl encoded a typical Ca2+-dependent carbohydrate-binding protein, and was mainly expressed in the liver in a tissue specific fashion. Challenge with LPS and LTA resulted in significant up-regulation of zhl expression, suggesting involvement in immune response. Actually, recombinant C-type lectin domain (rCTLD) of Zhl was found to be capable of agglutinating and binding to both Gram-negative and Gram-positive bacteria and enhancing the phagocytosis of the bacteria by macrophages. Moreover, rCTLD specifically bound to insoluble lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN), which were inhibited by galactose. Interestingly, Zhl was located in the membrane, and its overexpression could inhibit the production of pre-inflammatory cytokines. Taken together, these results indicate that Zhl has immune activity capable of defending invading pathogens, enriching our understanding of the function of ASGPR/hepatic lectin." @default.
• W2885266232 created "2018-08-22" @default.
• W2885266232 creator A5018419159 @default.
• W2885266232 creator A5033919240 @default.
• W2885266232 creator A5034730284 @default.
• W2885266232 creator A5049078993 @default.
• W2885266232 creator A5085775357 @default.
• W2885266232 creator A5086445887 @default.
• W2885266232 creator A5091904163 @default.
• W2885266232 date "2018-11-01" @default.
• W2885266232 modified "2023-10-12" @default.
• W2885266232 title "The hepatic lectin of zebrafish binds a wide range of bacteria and participates in immune defense" @default.
• W2885266232 cites W1487460006 @default.
• W2885266232 cites W1554604124 @default.
• W2885266232 cites W1662568066 @default.
• W2885266232 cites W1839631757 @default.
• W2885266232 cites W1965508264 @default.
• W2885266232 cites W1973646620 @default.
• W2885266232 cites W1975562030 @default.
• W2885266232 cites W1979439298 @default.
• W2885266232 cites W1986353574 @default.
• W2885266232 cites W1987931053 @default.
• W2885266232 cites W1995744610 @default.
• W2885266232 cites W1998781301 @default.
• W2885266232 cites W1999768858 @default.
• W2885266232 cites W2001772098 @default.
• W2885266232 cites W2003099086 @default.
• W2885266232 cites W2005849080 @default.
• W2885266232 cites W2007235382 @default.
• W2885266232 cites W2007511778 @default.
• W2885266232 cites W2009923072 @default.
• W2885266232 cites W2010980655 @default.
• W2885266232 cites W2016416826 @default.
• W2885266232 cites W2016592867 @default.
• W2885266232 cites W2020969008 @default.
• W2885266232 cites W2028792773 @default.
• W2885266232 cites W2029752113 @default.
• W2885266232 cites W2031987212 @default.
• W2885266232 cites W2041612274 @default.
• W2885266232 cites W2042433863 @default.
• W2885266232 cites W2042581920 @default.
• W2885266232 cites W2053188090 @default.
• W2885266232 cites W2059883987 @default.
• W2885266232 cites W2072098306 @default.
• W2885266232 cites W2078040903 @default.
• W2885266232 cites W2085188889 @default.
• W2885266232 cites W2086638135 @default.
• W2885266232 cites W2094060747 @default.
• W2885266232 cites W2101994976 @default.
• W2885266232 cites W2104722369 @default.
• W2885266232 cites W2114571489 @default.
• W2885266232 cites W2125349610 @default.
• W2885266232 cites W2127558641 @default.
• W2885266232 cites W2141141988 @default.
• W2885266232 cites W2144674806 @default.
• W2885266232 cites W2146321853 @default.
• W2885266232 cites W2149233086 @default.
• W2885266232 cites W2153548587 @default.
• W2885266232 cites W2160327135 @default.
• W2885266232 cites W2163291656 @default.
• W2885266232 cites W2167850644 @default.
• W2885266232 cites W2170602867 @default.
• W2885266232 cites W2173015905 @default.
• W2885266232 cites W2296019405 @default.
• W2885266232 cites W2400393709 @default.
• W2885266232 cites W2413656304 @default.
• W2885266232 cites W2517803660 @default.
• W2885266232 cites W2528921172 @default.
• W2885266232 cites W2760509283 @default.
• W2885266232 cites W383575 @default.
• W2885266232 cites W4245248161 @default.
• W2885266232 doi "https://doi.org/10.1016/j.fsi.2018.08.012" @default.
• W2885266232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30120977" @default.
• W2885266232 hasPublicationYear "2018" @default.
• W2885266232 type Work @default.
• W2885266232 sameAs 2885266232 @default.
• W2885266232 citedByCount "15" @default.
• W2885266232 countsByYear W28852662322019 @default.
• W2885266232 countsByYear W28852662322020 @default.
• W2885266232 countsByYear W28852662322021 @default.
• W2885266232 countsByYear W28852662322022 @default.
• W2885266232 countsByYear W28852662322023 @default.
• W2885266232 crossrefType "journal-article" @default.
• W2885266232 hasAuthorship W2885266232A5018419159 @default.
• W2885266232 hasAuthorship W2885266232A5033919240 @default.
• W2885266232 hasAuthorship W2885266232A5034730284 @default.
• W2885266232 hasAuthorship W2885266232A5049078993 @default.
• W2885266232 hasAuthorship W2885266232A5085775357 @default.
• W2885266232 hasAuthorship W2885266232A5086445887 @default.
• W2885266232 hasAuthorship W2885266232A5091904163 @default.
• W2885266232 hasConcept C104317684 @default.
• W2885266232 hasConcept C106257327 @default.
• W2885266232 hasConcept C11569505 @default.
• W2885266232 hasConcept C125235067 @default.
• W2885266232 hasConcept C160448771 @default.
• W2885266232 hasConcept C189413060 @default.
• W2885266232 hasConcept C202751555 @default.
• W2885266232 hasConcept C203014093 @default.

• next