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- W2885272816 abstract "Purpose: Kaurenoic acid (KA) is a natural diterpene presenting great diversity of biological activities described in the literature. KA is present in several plants, among them Mikania glomerata , from which it can be isolated as major component. Semi-synthetic procedures can provide interesting biologically active derivatives, as performed twice with KA in previous works, giving methoxylated KA and KA methyl ester. Both derivatives were evaluated for their anti-leishmanial potential. In this work we aim to obtain the methoxylated KA methyl ester to send it to anti-leishmanial assays. Methods: 500g crushed leaves were extracted with dichloromethane. This extract was submitted to vacuum liquid chromatography (VLC). The Hexane/Ethyl acetate (8:2) phase yielded kaurenoic acid after classical column chromatography. As described earlier, the methyl ester from KA was obtained and then submitted to methoxylation reaction. For each semi-synthetic procedure, 50mg of diterpene was used. The methoxylation reaction was carried out dissolving KA in methanol and adding some drops of concentrated sulfuric acid and stirring the reaction mixture for 18h at room temperature. Results: A sample of 11.5 g of extract were treated to give 400 mg of pure KA. The aimed product was obtained with 72% yield. NMR experiments confirmed the obtained structure, as well as the precursor. The product was sent to biological assays. Conclusion: As expected, the aimed product was obtained by combined procedures. The biological result can lead to an important conclusion about the structure-activity relationship for anti-leishmanial activity of these diterpenes." @default.
- W2885272816 created "2018-08-22" @default.
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- W2885272816 date "2018-06-15" @default.
- W2885272816 modified "2023-09-28" @default.
- W2885272816 title "OBTAINING AND PURIFYING KAURENOIC ACID DERIVATIVES AND ANTI-LEISHMANIAL ASSESSMENT" @default.
- W2885272816 hasPublicationYear "2018" @default.
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