Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885272870> ?p ?o ?g. }
- W2885272870 abstract "The proliferation and migration of intestinal epithelial cell is important to the barrier integrity of intestinal epithelium. Cucurbitacin E (CuE) is one of the tetracyclic triterpenoids extracted from the cucurbitaceae that has been shown to inhibit cancer cell growth, tumor angiogenesis and inflammatory response. Nevertheless, the role of Cucurbitacin E in regulating the proliferation and migration of intestinal epithelial cells remain unclear. In this study, the human intestinal epithelial cell line Caco-2 was treated with CuE and the effects of CuE on cell cycle, proliferation, migration and actin dynamics in Caco-2 cells were investigated successively. We found that CuE significantly inhibited the cell proliferation and migration, inducing the cell cycle arrest in G2/M phase and disrupting the actin dynamic balance in Caco-2 cells. Finally, we showed that CuE inhibited cofilin phosphorylation by suppressing the phosphorylation of both LIM kinase (LIMK)1 and LIMK2 in vitro, resulting in the activation of cofilin, which is closely associated with cell proliferation and migration. Therefore, our studies provided the first evidence that CuE inhibited the proliferation and migration of intestinal epithelial cells via activating cofilin, and CuE is a potential candidate in intestinal disease therapy." @default.
- W2885272870 created "2018-08-22" @default.
- W2885272870 creator A5027475930 @default.
- W2885272870 creator A5027834562 @default.
- W2885272870 creator A5037671724 @default.
- W2885272870 creator A5051765654 @default.
- W2885272870 creator A5085410795 @default.
- W2885272870 creator A5091383290 @default.
- W2885272870 date "2018-08-07" @default.
- W2885272870 modified "2023-10-06" @default.
- W2885272870 title "Cucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin" @default.
- W2885272870 cites W1828161921 @default.
- W2885272870 cites W1967379066 @default.
- W2885272870 cites W2001236611 @default.
- W2885272870 cites W2005677786 @default.
- W2885272870 cites W2014007588 @default.
- W2885272870 cites W2027416251 @default.
- W2885272870 cites W2030777833 @default.
- W2885272870 cites W2031869158 @default.
- W2885272870 cites W2038859574 @default.
- W2885272870 cites W2040265901 @default.
- W2885272870 cites W2041616575 @default.
- W2885272870 cites W2042945898 @default.
- W2885272870 cites W2063220206 @default.
- W2885272870 cites W2069433956 @default.
- W2885272870 cites W2074756197 @default.
- W2885272870 cites W2075850504 @default.
- W2885272870 cites W2080869873 @default.
- W2885272870 cites W2119793335 @default.
- W2885272870 cites W2119795339 @default.
- W2885272870 cites W2127164270 @default.
- W2885272870 cites W2136325098 @default.
- W2885272870 cites W2142942558 @default.
- W2885272870 cites W2143073532 @default.
- W2885272870 cites W2146473275 @default.
- W2885272870 cites W2158101161 @default.
- W2885272870 cites W2160239020 @default.
- W2885272870 cites W2162411580 @default.
- W2885272870 cites W2171444535 @default.
- W2885272870 cites W2200361686 @default.
- W2885272870 cites W2206412447 @default.
- W2885272870 cites W2237928862 @default.
- W2885272870 cites W2267664229 @default.
- W2885272870 cites W2321318697 @default.
- W2885272870 cites W2324903944 @default.
- W2885272870 cites W2374873025 @default.
- W2885272870 cites W2469253779 @default.
- W2885272870 cites W2472516939 @default.
- W2885272870 cites W2473357402 @default.
- W2885272870 cites W2505198895 @default.
- W2885272870 doi "https://doi.org/10.3389/fphys.2018.01090" @default.
- W2885272870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6090878" @default.
- W2885272870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30131725" @default.
- W2885272870 hasPublicationYear "2018" @default.
- W2885272870 type Work @default.
- W2885272870 sameAs 2885272870 @default.
- W2885272870 citedByCount "12" @default.
- W2885272870 countsByYear W28852728702019 @default.
- W2885272870 countsByYear W28852728702020 @default.
- W2885272870 countsByYear W28852728702021 @default.
- W2885272870 countsByYear W28852728702022 @default.
- W2885272870 countsByYear W28852728702023 @default.
- W2885272870 crossrefType "journal-article" @default.
- W2885272870 hasAuthorship W2885272870A5027475930 @default.
- W2885272870 hasAuthorship W2885272870A5027834562 @default.
- W2885272870 hasAuthorship W2885272870A5037671724 @default.
- W2885272870 hasAuthorship W2885272870A5051765654 @default.
- W2885272870 hasAuthorship W2885272870A5085410795 @default.
- W2885272870 hasAuthorship W2885272870A5091383290 @default.
- W2885272870 hasBestOaLocation W28852728701 @default.
- W2885272870 hasConcept C11960822 @default.
- W2885272870 hasConcept C137738243 @default.
- W2885272870 hasConcept C142669718 @default.
- W2885272870 hasConcept C1491633281 @default.
- W2885272870 hasConcept C185592680 @default.
- W2885272870 hasConcept C2776601116 @default.
- W2885272870 hasConcept C2781077229 @default.
- W2885272870 hasConcept C29537977 @default.
- W2885272870 hasConcept C2993400109 @default.
- W2885272870 hasConcept C529295009 @default.
- W2885272870 hasConcept C54355233 @default.
- W2885272870 hasConcept C55493867 @default.
- W2885272870 hasConcept C62112901 @default.
- W2885272870 hasConcept C86803240 @default.
- W2885272870 hasConcept C95444343 @default.
- W2885272870 hasConceptScore W2885272870C11960822 @default.
- W2885272870 hasConceptScore W2885272870C137738243 @default.
- W2885272870 hasConceptScore W2885272870C142669718 @default.
- W2885272870 hasConceptScore W2885272870C1491633281 @default.
- W2885272870 hasConceptScore W2885272870C185592680 @default.
- W2885272870 hasConceptScore W2885272870C2776601116 @default.
- W2885272870 hasConceptScore W2885272870C2781077229 @default.
- W2885272870 hasConceptScore W2885272870C29537977 @default.
- W2885272870 hasConceptScore W2885272870C2993400109 @default.
- W2885272870 hasConceptScore W2885272870C529295009 @default.
- W2885272870 hasConceptScore W2885272870C54355233 @default.
- W2885272870 hasConceptScore W2885272870C55493867 @default.
- W2885272870 hasConceptScore W2885272870C62112901 @default.
- W2885272870 hasConceptScore W2885272870C86803240 @default.
- W2885272870 hasConceptScore W2885272870C95444343 @default.