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- W2885283798 abstract "Abstract—Expression of the voltage-gated K+ channel Kv2.1, a possible molecular correlate for the cardiac delayed rectifier current (IK), has recently been shown to vary between individual ventricular myocytes. The functional consequences of this cell-to-cell heterogeneity in Kv2.1 expression are not known. Using multiplex single-cell reverse transcriptase–polymerase chain reaction (RT-PCR), we detected Kv2.1 mRNA in 47% of isolated midmyocardial myocytes from the rat left ventricular free wall that were positive for α-myosin heavy chain mRNA (n=74). Whole-cell patch-clamp recordings demonstrated marked differences in the magnitude of IK (200 to 1450 pA at VPip=40 mV) between individual myocytes of the same origin. Furthermore, the tetraethylammonium (TEA)–sensitive outward current (ITEA), known to be partly encoded by Kv2.1 in mice, revealed a wide range of current magnitudes between single cells (150 to 1130 pA at VPip=40 mV). Combined patch-clamp recordings and multiplex single-cell RT-PCR analysis of ..." @default.
- W2885283798 created "2018-08-22" @default.
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- W2885283798 date "2001-03-16" @default.
- W2885283798 modified "2023-09-23" @default.
- W2885283798 title "Heterogeneity of Kv2.1 mRNA Expression and Delayed Rectifier Current in Single Isolated Myocytes From Rat Left Ventricle" @default.
- W2885283798 hasPublicationYear "2001" @default.
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