FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885284676> ?p ?o ?g. }

• W2885284676 abstract "The present study focuses on isolation and evaluation of the anti-cancer activity of compounds from the leaves of Abrus precatorius. The bioassay-directed strategy was adopted using chromatographic, gas chromatographic–mass spectrum analysis, nuclear magnetic resonance and X-ray crystallography techniques for purification and characterization of active cytotoxic compounds. Further, MDA-MB-231 breast cancer cell lines and 7,12-dimethylbenz (a) anthracene (DMBA) induced virgin female Sprague Dawley (SD) rats were used for in vitro and in vivo cytotoxicity evaluation. Stigmasterol hemihydrate and 9,12-Octadecadienoic acid (Z,Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester or (β-monolinolein) were the two main cytotoxic constituents of leaf extract of A. precatorius, with an IC50 value of 74.2 and 13.2 µg/ml, respectively, in MDA-MB-231 cells. Additionally, the treatment with the stigmasterol and β-monolinolein as a combinatorial drug therapy in DMBA-induced female SD rats led to recovery of body weight, decreased tumor weight and volume, without any toxic side effects. Immunohistochemical examination showed extensive cell death and low proliferation in the treated tumor tissues that was confirmed by results from H and E staining, TUNEL assay and Ki-67 index as compared to control animal group. The reversion of glycoprotein, lysosomal and tumor marker enzyme levels back to near-normal levels after treatment with the plant compounds clearly demonstrated the reduction of tumor burden in these animals. This is the first report on isolation and characterization of the two active cytotoxic components from leaves of A. precatorius. Additionally, the profound cytotoxic and tumor-suppressive effect of these two compounds as a combinatorial therapy provide an alternative option for breast cancer treatment." @default.
• W2885284676 created "2018-08-22" @default.
• W2885284676 creator A5005134377 @default.
• W2885284676 creator A5014563838 @default.
• W2885284676 creator A5061996976 @default.
• W2885284676 creator A5087567360 @default.
• W2885284676 creator A5089560102 @default.
• W2885284676 date "2018-08-01" @default.
• W2885284676 modified "2023-10-14" @default.
• W2885284676 title "Chemopreventive and anti-breast cancer activity of compounds isolated from leaves of Abrus precatorius L." @default.
• W2885284676 cites W1481157130 @default.
• W2885284676 cites W1508025216 @default.
• W2885284676 cites W1561709121 @default.
• W2885284676 cites W1580023435 @default.
• W2885284676 cites W1603191902 @default.
• W2885284676 cites W1963629796 @default.
• W2885284676 cites W1970418024 @default.
• W2885284676 cites W1974068481 @default.
• W2885284676 cites W1981258503 @default.
• W2885284676 cites W1983151599 @default.
• W2885284676 cites W1986553386 @default.
• W2885284676 cites W1990596865 @default.
• W2885284676 cites W1995156715 @default.
• W2885284676 cites W1997430296 @default.
• W2885284676 cites W1999171842 @default.
• W2885284676 cites W2036373986 @default.
• W2885284676 cites W2041997034 @default.
• W2885284676 cites W2055014258 @default.
• W2885284676 cites W2064227891 @default.
• W2885284676 cites W2074629712 @default.
• W2885284676 cites W2083260383 @default.
• W2885284676 cites W2083788758 @default.
• W2885284676 cites W2088249292 @default.
• W2885284676 cites W2089434551 @default.
• W2885284676 cites W2093467508 @default.
• W2885284676 cites W2106787323 @default.
• W2885284676 cites W2117946804 @default.
• W2885284676 cites W2120925877 @default.
• W2885284676 cites W2139107535 @default.
• W2885284676 cites W2155582360 @default.
• W2885284676 cites W2160848470 @default.
• W2885284676 cites W2162620967 @default.
• W2885284676 cites W2311660836 @default.
• W2885284676 cites W2326544807 @default.
• W2885284676 cites W2412240356 @default.
• W2885284676 cites W2415015899 @default.
• W2885284676 doi "https://doi.org/10.1007/s13205-018-1395-8" @default.
• W2885284676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6087508" @default.
• W2885284676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30105196" @default.
• W2885284676 hasPublicationYear "2018" @default.
• W2885284676 type Work @default.
• W2885284676 sameAs 2885284676 @default.
• W2885284676 citedByCount "16" @default.
• W2885284676 countsByYear W28852846762020 @default.
• W2885284676 countsByYear W28852846762021 @default.
• W2885284676 countsByYear W28852846762022 @default.
• W2885284676 countsByYear W28852846762023 @default.
• W2885284676 crossrefType "journal-article" @default.
• W2885284676 hasAuthorship W2885284676A5005134377 @default.
• W2885284676 hasAuthorship W2885284676A5014563838 @default.
• W2885284676 hasAuthorship W2885284676A5061996976 @default.
• W2885284676 hasAuthorship W2885284676A5087567360 @default.
• W2885284676 hasAuthorship W2885284676A5089560102 @default.
• W2885284676 hasBestOaLocation W28852846762 @default.
• W2885284676 hasConcept C109316439 @default.
• W2885284676 hasConcept C150903083 @default.
• W2885284676 hasConcept C154317977 @default.
• W2885284676 hasConcept C185592680 @default.
• W2885284676 hasConcept C202751555 @default.
• W2885284676 hasConcept C207001950 @default.
• W2885284676 hasConcept C2778016309 @default.
• W2885284676 hasConcept C2781087876 @default.
• W2885284676 hasConcept C43617362 @default.
• W2885284676 hasConcept C55493867 @default.
• W2885284676 hasConcept C556039675 @default.
• W2885284676 hasConcept C71924100 @default.
• W2885284676 hasConcept C86803240 @default.
• W2885284676 hasConcept C98274493 @default.
• W2885284676 hasConceptScore W2885284676C109316439 @default.
• W2885284676 hasConceptScore W2885284676C150903083 @default.
• W2885284676 hasConceptScore W2885284676C154317977 @default.
• W2885284676 hasConceptScore W2885284676C185592680 @default.
• W2885284676 hasConceptScore W2885284676C202751555 @default.
• W2885284676 hasConceptScore W2885284676C207001950 @default.
• W2885284676 hasConceptScore W2885284676C2778016309 @default.
• W2885284676 hasConceptScore W2885284676C2781087876 @default.
• W2885284676 hasConceptScore W2885284676C43617362 @default.
• W2885284676 hasConceptScore W2885284676C55493867 @default.
• W2885284676 hasConceptScore W2885284676C556039675 @default.
• W2885284676 hasConceptScore W2885284676C71924100 @default.
• W2885284676 hasConceptScore W2885284676C86803240 @default.
• W2885284676 hasConceptScore W2885284676C98274493 @default.
• W2885284676 hasIssue "8" @default.
• W2885284676 hasLocation W28852846761 @default.
• W2885284676 hasLocation W28852846762 @default.
• W2885284676 hasLocation W28852846763 @default.
• W2885284676 hasLocation W28852846764 @default.
• W2885284676 hasOpenAccess W2885284676 @default.
• W2885284676 hasPrimaryLocation W28852846761 @default.
• W2885284676 hasRelatedWork W1592261125 @default.

• next