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- W2885286979 abstract "<p><strong><em>Background:</em></strong><em> Periodontitis have a bidirectional relationship with diabetes mellitus, both can increase oxidative stress that trigger an increase of pro-inflammatory cytokines, such as TNF-α. Sea cucumbers have anti-inflammatory component that act to inhibit the release of inflammatory mediators. Hyperbaric oxygen therapy reduce oxidative stress. <strong>Purpose: </strong>The aim of this study is to investigate the effect of the sea cucumber powder and hyperbaric oxygen therapy on the expression of TNF-α in rats with diabetes mellitus induced by P.gingivalis bacteria. <strong>Materials and Methods: </strong>The study was an experimental laboratories<strong> </strong>research with factorial design. Twenty wistar rats were divided into 5 groups. K0 negative control, K1 positive control. K1-K4 groups were induced with streptozotocin for diabetes condition<strong> </strong>and<strong> </strong>P.gingivalis bacteria for periodontitis condition. K2 group was treated with sea<strong> </strong>cucumber 3% for 7 days, K3 with<strong> </strong></em><em>OHB </em><em>2.4 ATA 3 x 30’ interval 5’ for 7 days, and K4 group was treated with combination of sea cucumber and OHB.<strong> </strong>At the 51<sup>st</sup> day all rats were sacrified, then the expression of TNF-α on periodontal macrophages were examined by immunohistochemistry stain. Data were analized by Kruskal Wallis followed by Mann-whitney.<strong> Result: </strong>Expression of TNF-α were increased in K1 (11.50±1.291) compare K0 (p<0.05). Sea cucumber treatment, OHB, and combination treatment decreased expression of TNF-α significantly in amount of 2.50±0.577 (K2), 8.25±2.217 (K3), 3.00±0.816 (K4).<strong> Conclusion: </strong>Sea cucumber powder and OHB therapy affected the expression of TNF-α in rats with diabetes mellitus induced by P. gingivalis bacteria.</em></p>" @default.
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- W2885286979 date "2016-02-01" @default.
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- W2885286979 title "The Effect Of Sea Cucumber Powder And Hyperbaric Oxygen Therapy On The Expression Of Tumor Necrosis Factor Alfa In Rats With Diabetes Mellitus Induced By Porphyromonas gingivalis" @default.
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- W2885286979 doi "https://doi.org/10.30649/denta.v10i1.40" @default.
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