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• W2885287768 endingPage "477" @default.
• W2885287768 startingPage "449" @default.
• W2885287768 abstract "Rapid progress has been made in understanding the biology of adenocarcinoma of the colon and rectum. Tumor-suppressing genes, mutations in proto-oncogenes, and a gene that increases genetic instability that are associated with the neoplastic transformation of sporadic and familial colorectal carcinomas have been identified. Advances in understanding the genetic alterations that underlie neoplastic transformation suggest that there are at least two distinct pathways for the induction of invasive colorectal carcinoma. Elucidation of both the genetic and phenotypic alterations is slowly leading to better methods of prognostication for patients with carcinoma of the colon or rectum. It soon may be possible to identify and treat individuals at risk for colorectal carcinoma before they develop preneoplastic lesions as well as to target isolated, defined genetic defects for therapy." @default.
• W2885287768 created "2018-08-22" @default.
• W2885287768 creator A5006546115 @default.
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• W2885287768 creator A5071994103 @default.
• W2885287768 creator A5075272171 @default.
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• W2885287768 creator A5081915207 @default.
• W2885287768 date "1994-07-01" @default.
• W2885287768 modified "2023-09-29" @default.
• W2885287768 title "Molecular Biology of Neoplastic Transformation of the Large Bowel: Identification of Two Etiologic Pathways" @default.
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