Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885288907> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2885288907 abstract "Background: Redox imbalance is the primary cause for endothelial dysfunction (ED), obstructed blood flow, and subsequent heart attack and failure. Under oxidant stress, many critical proteins regulating endothelial function undergo oxidative modifications that lead to ED. Cellular levels of glutathione (GSH), the primary reducing source, can significantly regulate cell function via reversible protein thiol modification. N-Acetyl cysteine (NAC), a precursor for GSH biosynthesis, is beneficial for many vascular diseases; however, the detailed mechanism of these benefits is still not clear. Methods: We employed EPR spin-trapping, HPLC, fluorescent microscopy, immunoblotting, and qPCR of both in vitro and ex vivo experiments using either cultured cells or the Langendorff heart preparation. Results: NAC treatment increases NO generation from endothelial cells, as well as the enzyme and cofactor responsible for its production, ie eNOS and BH4. Interestingly, NAC treatment also increased the expression of DUSP4,..." @default.
- W2885288907 created "2018-08-22" @default.
- W2885288907 creator A5007649877 @default.
- W2885288907 creator A5016358314 @default.
- W2885288907 creator A5031476411 @default.
- W2885288907 creator A5050312346 @default.
- W2885288907 creator A5076416848 @default.
- W2885288907 creator A5089496566 @default.
- W2885288907 date "2014-07-18" @default.
- W2885288907 modified "2023-09-23" @default.
- W2885288907 title "Abstract 215: The Redox Activation of DUSP4 by N-Acetyl Cysteine Protects Endothelial Cells and the Myocardium against Oxidative Damage" @default.
- W2885288907 hasPublicationYear "2014" @default.
- W2885288907 type Work @default.
- W2885288907 sameAs 2885288907 @default.
- W2885288907 citedByCount "0" @default.
- W2885288907 crossrefType "journal-article" @default.
- W2885288907 hasAuthorship W2885288907A5007649877 @default.
- W2885288907 hasAuthorship W2885288907A5016358314 @default.
- W2885288907 hasAuthorship W2885288907A5031476411 @default.
- W2885288907 hasAuthorship W2885288907A5050312346 @default.
- W2885288907 hasAuthorship W2885288907A5076416848 @default.
- W2885288907 hasAuthorship W2885288907A5089496566 @default.
- W2885288907 hasConcept C123012128 @default.
- W2885288907 hasConcept C134018914 @default.
- W2885288907 hasConcept C181199279 @default.
- W2885288907 hasConcept C185592680 @default.
- W2885288907 hasConcept C197957613 @default.
- W2885288907 hasConcept C202751555 @default.
- W2885288907 hasConcept C26291073 @default.
- W2885288907 hasConcept C2776151105 @default.
- W2885288907 hasConcept C2776992346 @default.
- W2885288907 hasConcept C2777622882 @default.
- W2885288907 hasConcept C2778326061 @default.
- W2885288907 hasConcept C2779201268 @default.
- W2885288907 hasConcept C2780972559 @default.
- W2885288907 hasConcept C48349386 @default.
- W2885288907 hasConcept C538909803 @default.
- W2885288907 hasConcept C55493867 @default.
- W2885288907 hasConcept C57600042 @default.
- W2885288907 hasConcept C86803240 @default.
- W2885288907 hasConcept C95444343 @default.
- W2885288907 hasConceptScore W2885288907C123012128 @default.
- W2885288907 hasConceptScore W2885288907C134018914 @default.
- W2885288907 hasConceptScore W2885288907C181199279 @default.
- W2885288907 hasConceptScore W2885288907C185592680 @default.
- W2885288907 hasConceptScore W2885288907C197957613 @default.
- W2885288907 hasConceptScore W2885288907C202751555 @default.
- W2885288907 hasConceptScore W2885288907C26291073 @default.
- W2885288907 hasConceptScore W2885288907C2776151105 @default.
- W2885288907 hasConceptScore W2885288907C2776992346 @default.
- W2885288907 hasConceptScore W2885288907C2777622882 @default.
- W2885288907 hasConceptScore W2885288907C2778326061 @default.
- W2885288907 hasConceptScore W2885288907C2779201268 @default.
- W2885288907 hasConceptScore W2885288907C2780972559 @default.
- W2885288907 hasConceptScore W2885288907C48349386 @default.
- W2885288907 hasConceptScore W2885288907C538909803 @default.
- W2885288907 hasConceptScore W2885288907C55493867 @default.
- W2885288907 hasConceptScore W2885288907C57600042 @default.
- W2885288907 hasConceptScore W2885288907C86803240 @default.
- W2885288907 hasConceptScore W2885288907C95444343 @default.
- W2885288907 hasLocation W28852889071 @default.
- W2885288907 hasOpenAccess W2885288907 @default.
- W2885288907 hasPrimaryLocation W28852889071 @default.
- W2885288907 hasRelatedWork W1887299580 @default.
- W2885288907 hasRelatedWork W1980021377 @default.
- W2885288907 hasRelatedWork W2000243579 @default.
- W2885288907 hasRelatedWork W2011846287 @default.
- W2885288907 hasRelatedWork W2021460138 @default.
- W2885288907 hasRelatedWork W2030093453 @default.
- W2885288907 hasRelatedWork W2038822864 @default.
- W2885288907 hasRelatedWork W2040886415 @default.
- W2885288907 hasRelatedWork W2047381703 @default.
- W2885288907 hasRelatedWork W2049821479 @default.
- W2885288907 hasRelatedWork W2065146981 @default.
- W2885288907 hasRelatedWork W2080858809 @default.
- W2885288907 hasRelatedWork W2089984249 @default.
- W2885288907 hasRelatedWork W2117269334 @default.
- W2885288907 hasRelatedWork W2132789031 @default.
- W2885288907 hasRelatedWork W2252524287 @default.
- W2885288907 hasRelatedWork W2342492742 @default.
- W2885288907 hasRelatedWork W2592189823 @default.
- W2885288907 hasRelatedWork W2754970289 @default.
- W2885288907 hasRelatedWork W2792753178 @default.
- W2885288907 isParatext "false" @default.
- W2885288907 isRetracted "false" @default.
- W2885288907 magId "2885288907" @default.
- W2885288907 workType "article" @default.