Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885292080> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2885292080 abstract "Abstract The structure-function relationships of the sarcomeric proteins in the mammalian cardiac compartment remain ill-defined because of the lack of a suitable model in which they can be readily manipulated or exchanged in vivo. To establish the validity of the transgenic paradigm for remodeling the mammalian heart, the murine α-cardiac myosin heavy chain gene promoter was used to express a ventricular myosin light chain-2 transgene (MLC2v) in both the atria and ventricles of the adult animal. Expression resulted in high levels of the transgene’s transcript in both compartments. In the ventricle, the transgene was expressed against the background expression of the normal isoform. In the atrium, the transgene’s expression would be ectopic, in that normally, MLC2v expression is restricted to the ventricle. Ectopic expression of the transgene in the atria resulted in a complete replacement of the atrial myosin light chain-2 protein isoform, although the endogenous isoform’s steady state transcript levels ..." @default.
- W2885292080 created "2018-08-22" @default.
- W2885292080 creator A5033195451 @default.
- W2885292080 creator A5043548029 @default.
- W2885292080 creator A5060910190 @default.
- W2885292080 creator A5064831342 @default.
- W2885292080 creator A5066432583 @default.
- W2885292080 date "1996-03-01" @default.
- W2885292080 modified "2023-09-23" @default.
- W2885292080 title "Transgenic Remodeling of the Contractile Apparatus in the Mammalian Heart" @default.
- W2885292080 hasPublicationYear "1996" @default.
- W2885292080 type Work @default.
- W2885292080 sameAs 2885292080 @default.
- W2885292080 citedByCount "0" @default.
- W2885292080 crossrefType "journal-article" @default.
- W2885292080 hasAuthorship W2885292080A5033195451 @default.
- W2885292080 hasAuthorship W2885292080A5043548029 @default.
- W2885292080 hasAuthorship W2885292080A5060910190 @default.
- W2885292080 hasAuthorship W2885292080A5064831342 @default.
- W2885292080 hasAuthorship W2885292080A5066432583 @default.
- W2885292080 hasConcept C102230213 @default.
- W2885292080 hasConcept C104317684 @default.
- W2885292080 hasConcept C126322002 @default.
- W2885292080 hasConcept C141035611 @default.
- W2885292080 hasConcept C150194340 @default.
- W2885292080 hasConcept C207001950 @default.
- W2885292080 hasConcept C2778921608 @default.
- W2885292080 hasConcept C53345823 @default.
- W2885292080 hasConcept C54355233 @default.
- W2885292080 hasConcept C6997183 @default.
- W2885292080 hasConcept C71924100 @default.
- W2885292080 hasConcept C8035138 @default.
- W2885292080 hasConcept C86803240 @default.
- W2885292080 hasConcept C95444343 @default.
- W2885292080 hasConcept C97037327 @default.
- W2885292080 hasConceptScore W2885292080C102230213 @default.
- W2885292080 hasConceptScore W2885292080C104317684 @default.
- W2885292080 hasConceptScore W2885292080C126322002 @default.
- W2885292080 hasConceptScore W2885292080C141035611 @default.
- W2885292080 hasConceptScore W2885292080C150194340 @default.
- W2885292080 hasConceptScore W2885292080C207001950 @default.
- W2885292080 hasConceptScore W2885292080C2778921608 @default.
- W2885292080 hasConceptScore W2885292080C53345823 @default.
- W2885292080 hasConceptScore W2885292080C54355233 @default.
- W2885292080 hasConceptScore W2885292080C6997183 @default.
- W2885292080 hasConceptScore W2885292080C71924100 @default.
- W2885292080 hasConceptScore W2885292080C8035138 @default.
- W2885292080 hasConceptScore W2885292080C86803240 @default.
- W2885292080 hasConceptScore W2885292080C95444343 @default.
- W2885292080 hasConceptScore W2885292080C97037327 @default.
- W2885292080 hasLocation W28852920801 @default.
- W2885292080 hasOpenAccess W2885292080 @default.
- W2885292080 hasPrimaryLocation W28852920801 @default.
- W2885292080 hasRelatedWork W1557719847 @default.
- W2885292080 hasRelatedWork W1963799921 @default.
- W2885292080 hasRelatedWork W1968958542 @default.
- W2885292080 hasRelatedWork W1969076560 @default.
- W2885292080 hasRelatedWork W1979163680 @default.
- W2885292080 hasRelatedWork W1990704191 @default.
- W2885292080 hasRelatedWork W1994428135 @default.
- W2885292080 hasRelatedWork W2012425923 @default.
- W2885292080 hasRelatedWork W2024930167 @default.
- W2885292080 hasRelatedWork W2040816210 @default.
- W2885292080 hasRelatedWork W2139091946 @default.
- W2885292080 hasRelatedWork W2144433668 @default.
- W2885292080 hasRelatedWork W2184560410 @default.
- W2885292080 hasRelatedWork W2365095867 @default.
- W2885292080 hasRelatedWork W2410076027 @default.
- W2885292080 hasRelatedWork W2465888405 @default.
- W2885292080 hasRelatedWork W2474725460 @default.
- W2885292080 hasRelatedWork W2887303564 @default.
- W2885292080 hasRelatedWork W3146019218 @default.
- W2885292080 hasRelatedWork W3150256676 @default.
- W2885292080 isParatext "false" @default.
- W2885292080 isRetracted "false" @default.
- W2885292080 magId "2885292080" @default.
- W2885292080 workType "article" @default.