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- W2885293882 abstract "Abstract Premature infants are more likely to develop locomotor disorders than term infants. In a chronic sub-lethal hypoxia (Hx) mouse model of neonatal brain injury, we recently demonstrated the presence of cellular and physiological changes in the cerebellar white matter. We also observed Hx-induced delay in Purkinje cell (PC) arborization. However, the behavioral consequences of these cellular alterations remain unexplored. Using the Erasmus Ladder to study cerebellar behavior, we report the presence of locomotor malperformance and long-term cerebellar learning deficits in Hx mice. Optogenetics experiments in Hx mice reveal a profound reduction in spontaneous and photoevoked PC firing frequency. Finally, treatment with a gamma-aminobutyric acid (GABA) reuptake inhibitor partially rescues locomotor performance and improves PC firing. Our results demonstrate a long-term miscoordination phenotype characterized by locomotor malperformance and cerebellar learning deficits in a mouse model of neonatal brain injury. Our findings also implicate the developing GABA network as a potential therapeutic target for prematurity-related locomotor deficits." @default.
- W2885293882 created "2018-08-22" @default.
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- W2885293882 date "2018-08-13" @default.
- W2885293882 modified "2023-10-12" @default.
- W2885293882 title "Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction" @default.
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- W2885293882 cites W1866012920 @default.
- W2885293882 cites W1903210410 @default.
- W2885293882 cites W1926351161 @default.
- W2885293882 cites W1936685714 @default.
- W2885293882 cites W1971087529 @default.
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- W2885293882 cites W2012900395 @default.
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- W2885293882 cites W2016867289 @default.
- W2885293882 cites W2017818222 @default.
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- W2885293882 cites W2035354480 @default.
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- W2885293882 cites W2068828473 @default.
- W2885293882 cites W2075296781 @default.
- W2885293882 cites W2076504002 @default.
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- W2885293882 cites W2168986469 @default.
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- W2885293882 cites W2220795078 @default.
- W2885293882 cites W2320983896 @default.
- W2885293882 cites W2332285039 @default.
- W2885293882 cites W2413006896 @default.
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- W2885293882 doi "https://doi.org/10.1038/s41467-018-05656-w" @default.
- W2885293882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6089917" @default.
- W2885293882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30104642" @default.
- W2885293882 hasPublicationYear "2018" @default.
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