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- W2885293889 abstract "Abstract—Insulin resistance has been associated with hypertriglyceridemia, combined hyperlipidemia, and familial combined hyperlipidemia (FCHL). Whether all FCHL patients with different types of dyslipidemia have low insulin sensitivity has not been evaluated. We measured insulin sensitivity by the hyperinsulinemic euglycemic clamp with indirect calorimetry in 110 healthy controls and in 105 nondiabetic, FCHL family members: in 50 without dyslipidemia, in 19 with hypercholesterolemia (total cholesterol ≥7.7 mmol/L), in 22 with hypertriglyceridemia (total triglycerides ≥2.4 mmol/L in men 2.4 mmol/L in women), and in 14 with combined hyperlipidemia. During the hyperinsulinemic clamp, FCHL family members had higher free fatty acid levels than did controls (0.06±0.06 [mean±SD] in controls versus 0.16±0.11 in relatives without dyslipidemia versus 0.15±0.07 in hypercholesterolemic patients versus 0.29±0.14 in hypertriglyceridemic patients versus 0.27±0.17 mmol/L in patients with combined hyperlipidemia; P<0.001..." @default.
- W2885293889 created "2018-08-22" @default.
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- W2885293889 date "2000-01-01" @default.
- W2885293889 modified "2023-09-24" @default.
- W2885293889 title "Impaired Free Fatty Acid Suppression During Hyperinsulinemia Is a Characteristic Finding in Familial Combined Hyperlipidemia, but Insulin Resistance Is Observed Only in Hypertriglyceridemic Patients" @default.
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